Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis

Gastroenterology Research and Practice
Xiaorong GuoZhaoshen Li

Abstract

Background. Researchers have evaluated various molecular tests for improving the differential diagnosis of cystic lesions of the pancreas. Methods. Six electronic databases were searched for articles on molecular tests for the diagnosis of pancreatic cysts. Measures of accuracy were extracted from selected articles and pooled by the random-effects model. Summary receiver operating characteristic curves were used to analyze the overall accuracy of the molecular tests. Pooled sensitivity and specificity values [95% confidence intervals] are reported. Results. The systematic review included eight studies of 428 patients in total. We determined the sensitivities and specificities of tests for KRAS mutations (0.47 [0.39-0.54], 0.98 [0.93-0.99]) and loss of heterozygosity (0.63 [0.54-0.71], 0.76 [0.63-0.87]) for distinguishing mucinous from nonmucinous cysts, as well as the sensitivities and specificities of tests for KRAS mutations (0.59 [0.46-0.71], 0.78 [0.71-0.85]) and loss of heterozygosity (0.89 [0.78-0.96], 0.69 [0.60-0.76]) for differentiating malignant from benign cysts. Conclusion. Tests of KRAS mutations could confirm but not exclude a diagnosis of a mucinous or malignant pancreatic cyst.

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May 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Christoph F DietrichMichael Hocke
Nov 23, 2017·The Korean Journal of Internal Medicine·Michael HockeChristoph F Dietrich
Nov 12, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Takuji IwashitaMasahito Shimizu
Jun 1, 2019·World Journal of Gastroenterology : WJG·César Vivian Lopes
Jun 21, 2019·Current Opinion in Gastroenterology·Alecia M Blaszczak, Somashekar G Krishna
Aug 31, 2019·BioMed Research International·Ying WangEnqiang Linghu

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