Molecular analysis of a candidate gene for the reproductive isolation between sibling species of Drosophila

Experientia
Pierre Hutter, F Karch

Abstract

The X-linked gene Hmr in Drosophila melanogaster, when mutated, rescues otherwise inviable interspecific hybrids from crosses between D. melanogaster and any of its three most closely related species D. simulans, D. mauritiana and D. sechellia. DNA from the site of a breakpoint at the putative locus of the gene has been cloned, and results of transcription and sequence analyses are presented. Three distinct mRNAs are transcribed from this locus, two of which are abundantly expressed throughout life. A third transcript, which is larger but rarer, appears to be disrupted by at least one of the two known mutations of Hmr. The gene encodes a mitochondrial ADP/ATP translocator protein, which plays an essential role in maintaining metabolic energy. Analysis of several cDNAs suggested that the rescue of hybrids may be dependent on mutations in the variable 3' end region of this gene, affecting the level and/or the stability of the largest messenger RNA.

References

Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·G K SimN Rosenthal
Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Oct 1, 1990·Genetical Research·J L GuénetF Bonhomme
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J Houldsworth, G Attardi
Apr 1, 1987·Clinical & Experimental Metastasis·C W StackpoleA L Alterman
Feb 1, 1973·The Journal of Cell Biology·M L PolanW Gehring
Aug 1, 1980·Analytical Biochemistry·S C GirvitzF L Graham
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
Nov 15, 1983·Journal of Molecular Biology·A M FrischaufN Murray
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B G BarrellI G Young
Feb 11, 1993·Nature·H A Orr
Mar 26, 1920·Science·A H Sturtevant

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