Molecular analysis of a case of nevus of ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue nevus

The American Journal of Dermatopathology
Pedram GeramiBoris C Bastian

Abstract

Nevus of Ota is a variant of congenital nevus, which is morphologically paucicellular and resembles a common blue nevus. Although nevus of Ota is a risk factor for uveal melanoma in white people, the development of cutaneous melanoma within nevus of Ota is a very rare occurrence with only a few reported cases. We present a case of a long-standing nevus of Ota, with radiologic imaging demonstrating a large retro-orbital mass and a biopsy showing melanoma. The histopathology of the eye exenteration specimen illustrated various stages of melanocytic progression including areas resembling a nevus of Ota, blue nevus, cellular blue nevus, and melanoma. There was heterogeneity in the overtly malignant sections with some areas displaying expansile nodules of blander appearing spindled cells, whereas other areas were composed of epithelioid cells with higher mitotic counts and zones of necrosis. The extensive lesion also infiltrated the soft tissue and bone. We performed gene mutation analysis for GNAQ, BRAF, NRAS, and KIT and fluorescence in situ hybridization (FISH) targeting commonly altered chromosomal loci in melanoma and comparative genomic hybridization (CGH). Copy number changes typical of melanoma were identified by both FISH a...Continue Reading

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Citations

Jun 21, 2014·Journal of Ayurveda and Integrative Medicine·Sanjeev Rastogi, Priyanka Chaudhari
Dec 25, 2015·Pigment Cell & Melanoma Research·Ana VivancosJuan A Recio
Nov 14, 2012·Journal of Cutaneous Pathology·Jeffrey P NorthPhilip E LeBoit
Jun 26, 2012·Journal of Cutaneous Pathology·Timothy H McCalmont
Jan 22, 2011·Journal of Cutaneous Pathology·Bryan GammonPedram Gerami
May 29, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marion WobserHenning Hamm
May 7, 2016·Journal of Cutaneous Pathology·Julia DaiRosalie Elenitsas
Jun 17, 2015·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·R AndreiFlorica Staniceanu
Oct 26, 2018·Archives of Pathology & Laboratory Medicine·Jonathan J Lee, Christine G Lian
Aug 17, 2019·Current Molecular Medicine·Sacha Nahon-EstevePaul Hofman
Dec 6, 2018·Topics in Magnetic Resonance Imaging : TMRI·Felipe S BarrosBruno P Soares
Aug 19, 2020·International Journal of Dermatology·Natalie M WilliamsKeyvan Nouri
Feb 24, 2017·Cancer Metastasis Reviews·Adriana AmaroUlrich Pfeffer
Jul 8, 2014·The American Journal of Dermatopathology·Michelle HouangArnaud de la Fouchardiere
Jul 16, 2021·The American Journal of Surgical Pathology·Kathleen M SheahonUrsula E Lang
Jun 11, 2011·Biomarkers in Medicine·Konstantinos LinosJ Andrew Carlson
Oct 3, 2020·Ocular Oncology and Pathology·Kelsey A RoelofsBertil Damato

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