PMID: 2114283May 31, 1990Paper

Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesis

European Journal of Biochemistry
J A Campos-Ortega, E Knust

Abstract

In Drosophila melanogaster, the neuroblasts (neural progenitor cells) develop from a special region of the ectoderm, called the neuroectoderm. During early embryonic development, the neuroblasts separate from the remaining cells of the neuroectoderm, which develop as epidermoblasts (epidermal progenitor cells). The separation of these two cell types is the result of cellular interactions. The available data indicate that a signal chain formed by the products of several identified genes regulates the cell's decision to enter either neurogenesis or epidermogenesis. Various kinds of data, in particular from cell transplantation studies and from genetic and molecular analyses, suggest that the proteins encoded by the genes Notch and Delta interact at the membrane of the neuroectodermal cells to provide a regulatory signal. This signal is thought to lead, on the one hand, to epidermal development through the action of the genes of the Enhancer of split complex, a gene complex that encodes several functions related to the transduction and further processing of the signal, including the genetic regulation in the receiving cell; on the other hand, the signal is thought to lead to neural development through the participation of the gene...Continue Reading

References

Nov 1, 1979·Nature·F Jiménez, J A Campos-Ortega
Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
Sep 1, 1988·Trends in Neurosciences·J A Campos-Ortega
Aug 1, 1989·Genes & Development·S KiddM W Young
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W F Heath, R B Merrifield
Jul 1, 1987·Developmental Biology·E KnustJ A Campos-Ortega
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G M Technau, J A Campos-Ortega
May 20, 1988·Cell·B Furie, B C Furie
May 1, 1988·Genes & Development·A Ghysen, C Dambly-Chaudière
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M SasakiY Yamada
Sep 1, 1983·Cell·S KiddM W Young
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A KomoriyaJ Schlessinger
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Artavanis-TsakonasB Yedvobnick
Dec 1, 1984·Journal of Neurogenetics·U Dietrich, J A Campos-Ortega
Mar 1, 1937·Proceedings of the National Academy of Sciences of the United States of America·D F Poulson
Jul 1, 1987·Genetics·H Vässin, J A Campos-Ortega
Mar 1, 1988·Genetics·A de-la-ConchaJ A Campos-Ortega
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·Volker Hartenstein, Jose A Campos-Ortega

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Citations

Apr 1, 1991·Developmental Biology·D BettlerB Yedvobnick
Feb 1, 1994·Progress in Neurobiology·F HuangA Ghysen
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joung-Woo HongMichael S Levine
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T DickW Chia
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R P Harvey
Aug 5, 2009·Briefings in Functional Genomics & Proteomics·Vivek S Chopra, Mike Levine
Apr 1, 1991·The Journal of Clinical Investigation·S J Tapscott, H Weintraub
Dec 22, 2009·Trends in Molecular Medicine·Liyun SangHilary A Coller
Nov 25, 2004·Experimental Cell Research·Kei SakamotoAkira Yamaguchi
Jul 15, 2009·Seminars in Cell & Developmental Biology·Asuka Suzuki-Hirano, Tomomi Shimogori
Sep 10, 2013·Developmental Biology·Sandra MünderAngelika Böttger
Oct 11, 2016·Arthropod Structure & Development·Terri A Williams, Lisa M Nagy
May 16, 2020·Annual Review of Genomics and Human Genetics·Alexej Abyzov, Flora M Vaccarino
Aug 15, 2017·Genesis : the Journal of Genetics and Development·Fuki Gyoja
Nov 1, 1995·Journal of Neurogenetics·R M Twyman, E A Jones
Feb 1, 1992·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·José A Campos-Ortega, Marc Haenlin
Jun 27, 2018·PeerJ·Miguel A Mendoza-OrtízJuan R Riesgo-Escovar
Nov 1, 1990·Trends in Genetics : TIG·P Simpson
May 1, 1991·Trends in Biochemical Sciences·J R Woodgett
Dec 15, 1994·The Journal of Comparative Neurology·V HartensteinE Gruszynski-Defeo
Aug 18, 2021·International Journal of Radiation Biology·Neha AgrawalEkta Kohli

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