PMID: 9545520Apr 18, 1998Paper

Molecular analysis of a glucose-regulated gene (grp78) of Neurospora crassa

Biochimica Et Biophysica Acta
D TechelL Rensing

Abstract

The nucleotide sequence of the gene encoding the glucose-regulated protein 78 (GRP78) of Neurospora crassa was determined. The ORF codes for a protein of 662 amino acids (72 kDa) and belongs to the heat shock protein 70 (hsp70) gene family, which is characterized by three HSP70 'signature sequences'. The grp78 gene contains 5 introns. The protein carries the ER retention signal HDEL at its carboxy terminus and is most homologous to the KAR2/GRP78 protein of Saccharomyces cerevisiae (78%) and to KAR2/BiP of Yarrowia lipolytica (76%). The expression of grp78 is constitutive and can be enhanced by starvation, treatment with tunicamycin, the calcium ionophore A23187 or elevated temperatures (40 degrees C). An uninterrupted ORF was found on the reverse cDNA strand of grp78. The putative peptide shows 47% homology to the NAD-specific glutamate dehydrogenase of Achlya klebsiana.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R P ShiuI Pastan
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Aug 1, 1990·Die Naturwissenschaften·L Nover
May 1, 1987·Molecular and Cellular Biology·M R Slater, E A Craig
Jan 1, 1988·Molecular and Cellular Biology·S S Watowich, R I Morimoto
Nov 24, 1983·Nature·I G Haas, M Wabl
Mar 25, 1995·Nucleic Acids Research·P D SiebertS A Lukyanov
Jan 1, 1994·Critical Reviews in Eukaryotic Gene Expression·E LittleA S Lee
Jul 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C CamusJ L Vilde
Nov 29, 1996·The Journal of Biological Chemistry·A K Corsi, R Schekman
Aug 27, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan BazeleyBruce M Robinson

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Citations

Sep 4, 2004·Applied and Environmental Microbiology·Marta LombrañaJuan F Martín
Jan 28, 2006·FEMS Microbiology Reviews·James P BurnieRuth C Matthews
Aug 10, 2001·Fungal Genetics and Biology : FG & B·A ConesaC A van den Hondel
Apr 13, 2007·Journal of Molecular Biology·Dirk Tremmel, Maximilian Tropschug

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