PMID: 11336805May 5, 2001Paper

Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKepsilon

Biochimica Et Biophysica Acta
M V FrolovJ A Birchler

Abstract

Diacylglycerol kinase plays a central role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid thus initiating resynthesis of phosphatidylinositols. Diacylglycerol is a known second messenger reversibly activating protein kinase C. In addition, diacylglycerol is a potential precursor for polyunsaturated fatty acids. We describe the identification and molecular analysis of a novel type III Drosophila diacylglycerol kinase isoform, DGKepsilon. Drosophila DGKepsilon is mapped to the cytological position 49C1-3. DGKepsilon mRNA is 1.9 kb in length and is broadly distributed throughout development in different cells, primordia and organs, including testes. In embryogenesis, the transcripts are enriched in the cells, which are in S-phase or undergoing endoreplication. Comparison of the Drosophila DGKepsilon with the human homologue revealed that the first zinc finger-like motif is specific for the type III isoform. Although the testis-specific diacylglycerol kinase activity is dependent upon the dose of DGKepsilon gene, the deletion of DGKepsilon does not modulate the total cellular diacylglycerol level. In spite of a proposed key role of diacylglycerol kinase in termination of the diacylglycerol s...Continue Reading

References

Jan 1, 1978·Advances in Lipid Research·B J Holub, A Kuksis
Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Ravid, J A Spudich
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·I MasaiY Hotta
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M StrathmannM J Palazzolo
Feb 1, 1990·Trends in Biochemical Sciences·H KanohF Sakane
Nov 26, 1990·FEBS Letters·D SchaapR L van der Bend
Jul 15, 1990·The Biochemical Journal·M M Billah, J C Anthes
Aug 1, 1989·Journal of Molecular and Cellular Cardiology·M Hee-Cheong, D L Severson
Jul 18, 1986·Science·Y Nishizuka
Sep 11, 1986·Nature·W H MoolenaarS W de Laat
Jun 1, 1984·The Biochemical Journal·M J Berridge
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A C SpradlingG M Rubin
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K Goto, H Kondo
Sep 1, 1994·The American Journal of Physiology·M W Lee, D L Severson
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·D L HartlE R Lozovskaya
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I MasaiY Hotta
Aug 16, 1996·The Journal of Biological Chemistry·T M KlauckS Jaken
Jun 30, 1998·Trends in Biochemical Sciences·M N HodgkinM J Wakelam
Nov 26, 1998·The Journal of Biological Chemistry·L DingS M Prescott
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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