PMID: 8605093Mar 1, 1996Paper

Molecular analysis of HLA-DQB1 alleles in childhood common acute lymphoblastic leukaemia

British Journal of Cancer
S DeardenW G Bardsley

Abstract

Epidemiological studies suggest that childhood common acute lymphoblastic leukaemia (c-ALL) may be the rare outcome of early post-natal infection with a common infectious agent. One of the factors that may determine whether a child succumbs to c-ALL is how it responds to the candidate infection. Since immune responses to infection are under the partial control of (human leucocyte antigen) HLA genes, an association between an HLA allele and c-ALL could provide support for an infectious aetiology. To define the limit of c-ALL susceptibility within the HLA region, we have compared HLA-DQB1 allele frequencies in a cohort of 62 children with c-ALL with 76 newborn controls, using group-specific polymerase chain reaction (PCR) amplification, and single-strand conformation polymorphism (SSCP) analysis. We find that a significant excess of children with c-ALL type for DQB1*05 [relative risk (RR): 2.54, uncorrected P=0.038], and a marginal excess with DQB1*0501 (RR: 2.18; P=0.095). Only 3 of the 62 children with c-ALL have the other susceptibility allele, DPB1*0201 as well as DQB1*0501, whereas 15 had one or the other allele. This suggests that HLA-associated susceptibility may be determined independently by at least two loci, and is not...Continue Reading

Citations

Sep 2, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T Lehtinen, M Lehtinen
Aug 24, 2004·Oncogene·Charles A Stiller
Mar 22, 2012·International Journal of Hematology·Elias OroujiAfrouz Alipour
Dec 24, 2013·BioMed Research International·Javier Fernández-TorresAlberto López-Reyes
Feb 12, 2011·The Journal of International Medical Research·K OzdilliG Gedikoglu
Oct 17, 2008·Radiation Protection Dosimetry·Anand P Chokkalingam, Patricia A Buffler
Mar 24, 2015·Molecular and Clinical Oncology·Mervat M El AnsaryAlshymaa A Ahmed
Apr 11, 2018·Nature Communications·Jayaram VijayakrishnanRichard S Houlston

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