Molecular analysis of major histocompatibility complex allelic associations with systemic lupus erythematosus in Taiwan

Arthritis and Rheumatism
L Y LuP A Fraser

Abstract

To investigate the association of HLA class II alleles/haplotypes, type I C2 deficiency gene, and tumor necrosis factor a gene promoter allele (TNF2) with systemic lupus erythematosus (SLE) in the Chinese population in Taiwan. The HLA-DRB1 and DQB1 alleles were studied in 105 SLE patients and 115 controls by the polymerase chain reaction (PCR)/sequence-specific oligonucleotide probe method, the subtyping of DRB1*15/16 and DRB5 by PCR with sequence-specific primers, type I C2 deficiency gene by PCR, and TNF2 by PCR-Nco I restriction fragment length polymorphism. The frequencies of the HLA class II alleles DRB1*02, DRB1*1502, DRB5*0102, DQB1*0501, and DQB1*0602 and DR2-associated haplotypes DRB1* 1501,DRB5*0101,DQB1*0602 and DRB1*1502,DRB5* 0102,DQB1*0501 were higher among SLE patients than among controls; however, only DQB1*0501 was statistically significantly associated with SLE. No specific allele/haplotype was significantly associated with lupus nephritis. No subject had type I C2 deficiency. SLE patients had a marginally higher percentage of TNF2, which was in linkage disequilibrium with DR3. Since DR3 was not associated with SLE in this Taiwanese Chinese population, TNF2 might play a role in the immunopathogenesis of SLE. A...Continue Reading

References

Oct 1, 1976·The Journal of Clinical Investigation·D GlassP H Schur
Jan 1, 1986·Annual Review of Medicine·P H Schur
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Feb 1, 1981·The Journal of Clinical Investigation·Z L AwdehC A Alper
Jun 26, 1995·Biochemical and Biophysical Research Communications·A HamannJ S Flier
Mar 1, 1995·Immunology Today·A N Theofilopoulos
Jan 1, 1994·European Journal of Immunology·A G WilsonG W Duff
Jan 1, 1994·Scandinavian Journal of Rheumatology·H HashimotoS Hirose
May 1, 1994·British Journal of Rheumatology·J H Wilson, R L Wolman
Dec 1, 1995·Lupus·P H Schur
Jan 1, 1996·Tissue Antigens·N K MehraM J Giphart

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Citations

Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T PaisansinsupC S David
Dec 21, 2002·Immunological Reviews·Naoyuki TsuchiyaKatsushi Tokunaga
Jan 10, 2014·Journal of Clinical Immunology·Ning WangLennart Hammarström
Aug 13, 2015·Tissue Antigens·C KongmaroengA V Romphruk
May 16, 2001·Current Rheumatology Reports·B P Tsao, J M Grossman
Jul 20, 2002·Current Rheumatology Reports·Betty P Tsao
Jun 11, 2011·Immunology Letters·Yusmin Mohd-YusufSwan Sim Yeap

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