Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation

Journal of Human Genetics
Jan-Gowth ChangChing-Tien Peng

Abstract

The origins of the Taiwan aborigines have not been fully resolved. Anthropological and linguistic studies have indicated that their ancestry is mainly Austronesian or Malayopolynesian. Some polymorphisms and mutations in the secretor type alpha(1,2)-fucosyltransferase (FUT2) gene are found in Taiwan aborigines. In this study, we analyzed the frequency of eight mutations and one polymorphism of the FUT2 gene in Taiwan aborigines and other ethnic groups in order to explore the origins of these groups. The results showed that the C302T, G428A, and fusion gene mutations were specific for Thai, Caucasians, and Japanese, respectively. The A385T mutation was specific for Asians including Taiwan aborigines. The genetic frequencies of C571T were much higher in Taiwan aborigines (1.96% to 20.4%), Filipinos (13.2%), and Indonesians (3.30%) as compared with Thai (0.57%), Chinese (0.65% to 1.12%), Japanese (0%), and Caucasians (0%). The frequencies of the G849A mutation were also higher in Taiwan aborigines (0.38% to 21.57%), Filipinos (6.80%), and Indonesians (1.48%) than in Thai (0.94%), Chinese (0-0.37%), Japanese (0%), or Caucasians (0%). Deletion of a 3-bp region (nt 688 to nt 690) was found only in Filipinos (0.85%), Indonesians (0.74...Continue Reading

Citations

Feb 16, 2006·Journal of Clinical Pharmacy and Therapeutics·H-F LuJ-G Chang
Dec 11, 2007·Transfusion·Mikiko SoejimaYoshiro Koda
Jul 15, 2004·American Journal of Human Genetics·Li Shu-Chuan ChengYing-Chin Ko
Feb 14, 2014·Journal of Clinical Microbiology·Nguyen Van TrangDang Duc Anh
Apr 30, 2010·International Journal of Legal Medicine·Hsiao-Lin HwaTsang-Ming Ko
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y-L ChenJ-Y Wang

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