PMID: 15375513Sep 18, 2004Paper

Molecular analysis of PinX1 in human hepatocellular carcinoma

Oncology Reports
Bong-Kyeong OhYoung Nyun Park

Abstract

PinX1 is located at 8p23, a region with frequent loss of heterozygosity in hepatocellular carcinomas (HCCs). Overexpression of PinX1 is known to inhibit telomerase activity, shorten telomeres and induce crisis while its depletion increases tumorigenesis in nude mice. These results suggest that PinX1 might be critical for hepatocarcinogenesis. In this study, we assessed transcript expression of PinX1, the correlation between PinX1 mRNA level and telomere length and telomerase activity, as well as sequence alteration, in 24 HCCs and their adjacent non-HCC tissues from patients with B viral chronic hepatitis/cirrhosis. There was no significant difference between the levels of PinX1 mRNA in HCCs and those in non-HCCs. The PinX1 mRNA tended to increase as the telomere shortened in the HCCs (p=0.067, R(2)=0.166), but no correlation was found in non-HCCs. The PinX1 level revealed no significant relationship with telomerase activity in HCCs and non-HCCs. The missense mutations of PinX1, at the 254 and 265 residues, were found in 17% of the HCCs and their adjacent non-HCCs. The mutations were located in the non-conserved region and revealed no relation with PinX1 expression, telomere length and telomerase activity, suggesting that they ...Continue Reading

Citations

Mar 7, 2009·Journal of Molecular Biology·Jeong Eun YooYoung Nyun Park
Jan 3, 2007·Biochemical and Biophysical Research Communications·Jian LinJunJian Huang
Aug 14, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Min Sung KimSug Hyung Lee
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Bong-Kyeong OhYoung Nyun Park
Aug 25, 2016·Oncotarget·Hai-Long LiJun-Nian Zheng

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