PMID: 9174141May 1, 1997Paper

Molecular analysis of six dog leukocyte antigen class I sequences including three complete genes, two truncated genes and one full-length processed gene

Tissue Antigens
R C BurnettR Storb

Abstract

We have isolated six distinct dog leukocyte antigen (DLA) class I sequences. An additional functional nonclassical class I gene, DLA-79, was characterized previously. This brings the number of isolated canine class I sequences to seven. These seven loci account for nearly all class I sequences detected in genomic DNA by Southern blotting. With approximately seven members, the class I gene family in dog is considerably less complex than in either human or mouse. Three of the six sequences described in this article contain complete class I genes. These genes have the typical arrangement of exons and introns, and their predicted protein sequences have the features expected of expressed class I molecules. Two sequences contain truncated genes. These genes, having only partial class I homology and disruptive mutations, are clearly nonfunctional. The remaining locus contains a full-length processed gene which is unique among characterized class I loci. Sequence comparisons were performed to examine evolutionary relationships among the family members. Two sequences, DLA-64 (complete) and -53 (truncated), appear to be chimeras presumably formed by interlocus recombination. Using the reverse transcription-polymerase chain reaction, mRNA...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M A NowakJ M Austyn
Jan 15, 1992·Gene·M F MinnickG L Stiegler
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E GeraghtyD D Chaplin
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A Ishitani, D E Geraghty
Aug 1, 1990·Immunology Today·B David-WatineP Kourilsky
Jan 1, 1990·Immunogenetics·U M Sarmiento, R Storb
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R SrivastavaS M Weissman
Jul 1, 1988·The Journal of Experimental Medicine·J M ConnollyT H Hansen
Jan 1, 1989·Annual Review of Immunology·A Townsend, H Bodmer
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·W M Yokoyama
Jan 1, 1994·Annual Review of Immunology·S M ShawarR R Rich
Jun 1, 1993·Trends in Genetics : TIG·R K Wayne
Sep 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·R J Tatake, R A Zeff
Feb 1, 1993·Current Opinion in Immunology·D E Geraghty
Feb 1, 1993·Current Opinion in Immunology·J P Ting, A S Baldwin
Sep 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R C BurnettE A Ostrander
Sep 1, 1996·Tissue Antigens·J L WagnerR Storb

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Citations

Oct 3, 1999·Veterinary Immunology and Immunopathology·N C Pedersen
May 7, 2002·Nature Reviews. Cancer·Marie-Térèse Little, Rainer Storb
Sep 8, 2012·Ecology and Evolution·Yung Wa SinTerry Burke
Jul 12, 2005·Veterinary Immunology and Immunopathology·Chun XiaChangyou Lin
Apr 16, 2015·Journal of the American Veterinary Medical Association·Steven E SuterGopalakrishnan M Venkataraman
Jul 6, 2017·HLA : Immune Response Genetics·G M VenkataramanR Storb
May 16, 1998·Tissue Antigens·M B GraumannR Storb
Oct 16, 2021·British Poultry Science·Shujuan ZhaoYing Lei

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