Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan

The Journal of Cell Biology
Stefan KunzM B Oldstone

Abstract

alpha-Dystroglycan (DG) has been identified as the cellular receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa fever virus (LFV). This subunit of DG is a highly versatile cell surface molecule that provides a molecular link between the extracellular matrix (ECM) and a beta-DG transmembrane component, which interacts with the actin-based cytoskeleton. In addition, DG exhibits a complex pattern of interaction with a wide variety of ECM and cellular proteins. In the present study, we characterized the binding of LCMV to alpha-DG and addressed the role of alpha-DG-associated host-derived proteins in virus infection. We found that the COOH-terminal region of alpha-DG's first globular domain and the NH2-terminal region of the mucin-related structures of alpha-DG together form the binding site for LCMV. The virus-alpha-DG binding unlike ECM alpha-DG interactions was not dependent on divalent cations. Despite such differences in binding, LCMV and laminin-1 use, in part, an overlapping binding site on alpha-DG, and the ability of an LCMV isolate to compete with laminin-1 for receptor binding is determined by its binding affinity to alpha-DG. This competition of the virus with ECM molecules for receptor binding likely expla...Continue Reading

References

Sep 20, 1991·Cell·J M Ervasti, K P Campbell
Aug 1, 1983·The Journal of General Virology·F J Dutko, M B Oldstone
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·A J BettF L Graham
Aug 1, 1993·The Journal of Cell Biology·J M Ervasti, K P Campbell
Feb 16, 1996·The Journal of Biological Chemistry·E A PallJ M Ervasti
Dec 1, 1996·Journal of Virology·Y ChenR M Marks
May 15, 1997·European Journal of Biochemistry·A BrancaccioJ Engel
Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S K NilssonP S Becker
May 9, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M DurbeejP Ekblom
Dec 29, 1998·Cell·M D Henry, K P Campbell
Sep 3, 1999·The Journal of Biological Chemistry·M Durbeej, K P Campbell
Oct 6, 1999·Current Opinion in Cell Biology·M D Henry, K P Campbell
Dec 23, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M FalkP Ekblom
Nov 9, 2000·The Journal of Experimental Medicine·N SevillaM B Oldstone
Feb 13, 2001·Trends in Biochemical Sciences·S J Winder

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Citations

Jul 18, 2012·Immunology and Cell Biology·Alexandra RizzitelliPhillip I Bird
Mar 22, 2007·Nature Immunology·Michael B A Oldstone
Jul 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Renzhi HanKevin P Campbell
Jan 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brian M SullivanMichael B Oldstone
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yuji HaraKevin P Campbell
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anura RambukkanaMichael B A Oldstone
Dec 12, 2012·The Journal of Experimental Medicine·Helge FrebelAnnette Oxenius
Aug 22, 2006·The Journal of Infectious Diseases·Matthew J TrifiloMichael B A Oldstone
Jan 5, 2013·Brain : a Journal of Neurology·Sebahattin CirakFrancesco Muntoni
Jan 14, 2012·Glycobiology·Rebecca HarrisonStuart M Haslam
Jan 2, 2010·Science·Takako Yoshida-MoriguchiKevin P Campbell
Apr 26, 2012·Journal of Virology·Christelle PythoudStefan Kunz
Nov 30, 2007·Journal of Virology·Jillian M RojekStefan Kunz
Nov 26, 2010·Journal of Virology·Giulia PasqualStefan Kunz
Dec 14, 2011·Journal of Virology·Masayuki ShimojimaYoshihiro Kawaoka
Apr 23, 2002·Journal of Virology·Christina F SpiropoulouMichael B A Oldstone
Sep 29, 2004·Journal of Virology·Mar PerezJuan Carlos de la Torre
Jun 16, 2007·BMC Immunology·Charles H MarisJoshy Jacob
Aug 4, 2009·PLoS Pathogens·Michael B A Oldstone
Jan 25, 2013·Viruses·Juan C Zapata, Maria S Salvato
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Toshihiro Masaki, Kiichiro Matsumura
Aug 23, 2002·Immunological Reviews·Michael B A Oldstone
Nov 2, 2012·Cellular and Molecular Life Sciences : CMLS·Christina M DobsonLance Wells
Feb 3, 2016·DNA and Cell Biology·Michael B A Oldstone
Sep 13, 2011·Current Opinion in Virology·Cherie T NgMichael B A Oldstone
Feb 9, 2008·Trends in Immunology·Marianne M Martinic, Matthias G von Herrath
May 28, 2005·Journal of Cellular Physiology·Alessandro Sgambato, Andrea Brancaccio

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Methods Mentioned

BETA
Infection
glycosylation
PCR

Software Mentioned

KS300

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