Molecular analysis of the O alleles at the blood group ABO locus in populations of different ethnic origin reveals novel crossing-over events and point mutations

Biochemical and Biophysical Research Communications
M L OlssonM A Chester

Abstract

The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians. Several previously undescribed O alleles were found, predominantly in the Black group, in which about a third of the samples did not conform to previously known O allele structures. It has been well documented for the first time that some new alleles can arise from crossing-over events between known alleles in the ABO system. This was made possible by both restriction endonuclease analysis and direct sequencing of exons 3-7 in the ABO gene. The anticipated relatively high frequency of some of these new alleles in certain populations, necessitates great care when interpreting results from existing genotype screening methods.

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Citations

May 3, 2000·Clinical and Laboratory Haematology·M L Barjas-CastroS T Saad
Mar 16, 2002·Transfusion·Francis RoubinetAntoine Blancher
Jan 25, 2005·Vox Sanguinis·N SousaM L Barjas-Castro
Jan 24, 2007·International Journal of Legal Medicine·Kaori Shintani-IshidaKen-Ichi Yoshida
Jun 14, 2005·Legal Medicine·Koichi Suzuki
Jul 17, 2008·Human Genetics·Francesc CalafellAntoine Blancher
Sep 1, 2010·Expert Opinion on Medical Diagnostics·Franz F Wagner
Sep 9, 2004·British Journal of Haematology·Jill R Storry, Martin L Olsson
Aug 16, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J Downing, C Darke
Apr 24, 2004·Transfusion·Francis RoubinetJaume Bertanpetit
Sep 29, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Victoria S Sarafian, Tsvetana T Marinova
Oct 14, 2014·Scientific Reports·Fumiichiro YamamotoAntoine Blancher
Dec 17, 2009·Journal of Forensic Sciences·Li RuanQingge Li
May 3, 2000·Seminars in Hematology·M E ReidK Yazdanbakhsh

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