Molecular Analysis of Upper Tract and Bladder Urothelial Carcinoma: Results from a Microarray Comparison

PloS One
Thomas SanfordMaxwell V Meng

Abstract

Prior studies have shown genetic similarities between upper tract and bladder urothelial carcinoma. However, upper tract urothelial carcinoma tends to be higher grade than bladder urothelial carcinoma and tends to form in patients with certain familial conditions (e.g. Lynch Syndrome), indicating there may be unique biologic processes in these tumors. The purpose of this study was to evaluate the differences in gene expression between upper tract and bladder urothelial carcinoma using microarray data. A search of publicly available microarray datasets identified a clinically annotated dataset of 12 upper tract and 20 bladder urothelial carcinoma specimens. Gene expression analysis of data derived from the Affymetrix HGU133Plus2 chip was performed. Bioconductor packages were used to evaluate clustering, differential gene expression, pathways relevant to oncology, and a basal/luminal signature in upper tract versus bladder urothelial carcinoma. When separated by pathologic T stage, there was evidence of differential clustering among pT3 tumors and significant gene expression differences in 81 genes. Pathway analysis revealed differences in HGF and TNF signaling pathways. Upper tract tumors tended to have high expression of genes ...Continue Reading

References

Oct 12, 2000·The Journal of Urology·J J Munoz, L M Ellison
Jun 16, 2001·Cancer Genetics and Cytogenetics·M A RigolaR Miró
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Dec 4, 2004·The American Journal of Surgical Pathology·Semra OlgacVictor E Reuter
Mar 4, 2005·Journal of the Chinese Medical Association : JCMA·Pei-Hui ChanShei-Chain Tseng
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ekaterini BlaveriFrederic M Waldman
Jan 5, 2006·American Journal of Nephrology·Vladisav StefanovicMomir Polenakovic
Jul 12, 2007·Virchows Archiv : an International Journal of Pathology·Kuniaki NakanishiToshiaki Kawai
Jan 22, 2009·Cancer·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration
Dec 31, 2009·BJU International·Kenji UematsuToshiaki Kawai
Feb 23, 2013·Urologic Oncology·Nilay PatelJohn Kelly
Jan 31, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey S DamrauerWilliam Y Kim
Dec 17, 2014·Cancer Treatment Reviews·Benedito A CarneiroFrancis J Giles

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Citations

Feb 7, 2016·Urology·Rao S Mandalapu, Surena F Matin
May 24, 2018·Molecular Oncology·Christina TherkildsenFredrik Liedberg
Feb 19, 2019·American Journal of Clinical Pathology·Aileen Grace P ArriolaPriti Lal
Sep 2, 2016·Current Opinion in Urology·Solene-Florence Kammerer-JacquetKarim Bensalah
Sep 21, 2017·Oncology Letters·Yingbo HuZiming Shi
Aug 7, 2019·International Journal of Molecular Sciences·Georg C Hutterer
Jul 3, 2019·International Journal of Molecular Sciences·Huang-Yu YangKun-Lin Lu
Nov 27, 2019·Expert Review of Anticancer Therapy·Jacob TaylorVitaly Margulis
Jan 3, 2021·European Urology Oncology·John P SfakianosSumanta Pal
Jan 13, 2021·International Journal of Molecular Sciences·Andrea Katharina LindnerRenate Pichler
Mar 7, 2021·Genes·Elisa De LorenzisEmanuele Montanari
Aug 31, 2020·European Urology Focus·Andrea NecchiSiraj M Ali

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Datasets Mentioned

BETA
GSE
2109

Methods Mentioned

BETA
surgical resection

Clinical Trials Mentioned

NCT01963052

Software Mentioned

R package gplots
BRB
R
affy package
Parametric Gene Set Enrichment Analysis
ArrayTools
R package Parametric Gene Set Enrichment Analysis

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