Molecular and antigenic characteristics of Newcastle disease virus isolates from domestic ducks in China

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Wei WuShengwang Liu

Abstract

Newcastle disease (ND) is one of the most devastating diseases to the poultry industry. The causative agents of ND are virulent strains of Newcastle disease virus (NDV), which are members of the genus Avulavirus within the family Paramyxoviridae. Waterfowl, such as ducks and geese, are generally considered potential reservoirs of NDV and may show few or no clinical signs when infected with viruses that are obviously virulent in chickens. However, ND outbreaks in domestic waterfowl have been frequently reported in many countries in the past decade. In this study, 18 NDV strains isolated from domestic ducks in southern and eastern China, between 2005 and 2013, were genetically and phylogenetically characterized. The complete genomes of these strains were sequenced, and they exhibited genome sizes of 15,186 nucleotides (nt), 15,192 nt, and 15,198 nt, which follow the "rule of six" that is required for the replication of NDV strains. Based on the cleavage site of the F protein and pathogenicity tests in chickens, 17 of our NDV isolates were categorized as lentogenic viruses, and one was characterized as a velogenic virus. Phylogenetic analysis based on the partial sequences of the F gene and the complete genome sequences showed tha...Continue Reading

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Citations

Mar 8, 2016·Avian Pathology : Journal of the W.V.P.A·Shanhui RenZengqi Yang
May 27, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Qianqian XuShengwang Liu
Nov 27, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Abid HussainMasroor Ellahi Babar
Sep 21, 2018·Veterinary Research·Zaib Ur RehmanMuhammad Munir
Jun 14, 2020·Scientific Reports·Pachineella Lakshmana RaoMadhuri Subbiah
Feb 13, 2021·Avian Pathology : Journal of the W.V.P.A·Chiharu HidakaToshihiro Ito

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