Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-L-carnitine

Environmental Toxicology and Pharmacology
Amir BaghaeiMohammad Abdollahi

Abstract

The aim of the present study was to investigate the efficacy of acetyl-L-carnitine (ALCAR) on pathologic changes of mitochondrial respiratory chain activity, ATP production, oxidative stress, and cellular apoptosis/necrosis induced by aluminum phosphide (AlP) poisoning. The study groups included: the Sham that received almond oil only; the AlP that received oral LD50 dose of aluminum; the AC-100, AC-200, and AC-300 which received concurrent oral LD50 dose of AlP and single 100, 200, and 300 mg/kg of ALCAR by intraperitoneal injection. After 24 h, the rats were sacrificed; the heart and blood sample were taken for measurement of biochemical and mitochondrial factors. The results specified that ALCAR significantly attenuated the oxidative stress (elevated ROS and plasma iron levels) caused by AlP poisoning. ALCAR also increased the activity of cytochrome oxidase, which in turn amplified ATP production. Furthermore, flow cytometric assays and caspase activity indicated that ALCAR prohibited AlP-induced apoptosis in cardiomyocytes.

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Citations

Jul 20, 2016·Expert Opinion on Drug Metabolism & Toxicology·Mohammad Hossein AsghariMohammad Abdollahi
Apr 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Meng-Yu Zhang, Jie-Ping Wang
Apr 9, 2019·Arhiv za higijenu rada i toksikologiju·Mohammad-Reza BeyranvandShahin Shadnia
May 27, 2020·Cardiovascular Toxicology·Parinaz ParhizgarHossein Hassanian-Moghaddam
Nov 13, 2019·International Journal of Legal Medicine·Yue LiangYiwu Zhou
Sep 11, 2020·Clinical and Experimental Reproductive Medicine·Reyhane VardiyanAlireza Talebi
May 30, 2017·Archives of Toxicology·Mohammad Hossein AsghariMohammad Abdollahi
Jan 29, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Liuyan WuZhaoxin Tang
Feb 27, 2021·Biological Trace Element Research·LiuFang ZhouXi Wei
Jun 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahedeh SamadiMohammad Abdollahi
Oct 30, 2021·Toxicology Mechanisms and Methods·Mohammad Reza Hooshangi ShayestehMohammad Abdollahi

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