Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney

Saudi Journal of Biological Sciences
Omar Abdulhakeem Almaghrabi

Abstract

The present study was aimed to investigate the ability of quercetin (QE) to ameliorate adverse effects of cisplatin (Cis.) on the renal tissue antioxidants by investigating the kidney antioxidant gene expression and the antioxidant enzymes activity. Forty rats divided into. Control rats. QE treated rats were orally administered 100 mg QE/kg for successive 30 days. Cis. injected rats were administered i.p. Cis. (12 mg/kg b.w.) for 5 mutual days. Cis. + QE rats were administered Cis. i.p. (12 mg/kg) and orally administered 100 mg QE/kg for consecutive 30 days. The obtained results indicated that Cis. induced oxidative stress in the renal tissue. That was through induction of free radical production, inhibition of the activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) as well their genes expression. At the same time, vitamin E, vitamin C and reduced glutathione (GSH) levels were decreased. QE had the ability to overcome cisplatin-induced oxidative stress through the reduction of free radical levels. The antioxidant genes expression and antioxidant enzymes activity were induced. Finally the vitamin E, vitamin C and GSH levels were increased. Our work, proved the reno...Continue Reading

References

Jan 1, 1978·Biochemical Pharmacology·Y Masuda, T Murano
Aug 23, 1976·Biochemical and Biophysical Research Communications·R A Lawrence, R F Burk
Oct 1, 1969·The Journal of Clinical Investigation·E Beutler
Feb 1, 1984·Biochemical Pharmacology·M Ogata, H Aikoh
May 1, 2001·Journal of Clinical Pathology·D KoracevicV Cosic
Jun 23, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C R SilvaM L Bianchi
Sep 25, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·Q HuangK T Blanchard
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Aug 19, 2007·The American Journal of the Medical Sciences·Xin YaoKenneth Nugent
Jan 6, 2009·Biological & Pharmaceutical Bulletin·Ihab Talat Abdel-RaheemGamal Abdallah Mohamed
May 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Penelope D Sanchez-GonzalezJose M Lopez-Novoa
Nov 10, 2011·Toxins·Ronald P MillerWilliam Brian Reeves
May 4, 2012·BMC Complementary and Alternative Medicine·Laila M FaddahMuhammad Atteya
Jan 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·S Noori, Tabassum Mahboob
Jan 3, 2013·Psychiatry and Clinical Neurosciences·Mustafa GulecHalis Suleyman
Feb 4, 2014·Journal of Molecular Neuroscience : MN·Haytham Abdallah AliYahia Youssef Mosleh

❮ Previous
Next ❯

Citations

Feb 16, 2016·Chemico-biological Interactions·K V AthiraMangala Lahkar
Apr 2, 2016·Pharmacognosy Research·Oluwatosin Adekunle AdaramoyeOlufunke Elizabeth Ola-Davies
Jun 7, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sabiha FatimaSadia Arjumand
May 28, 2016·Expert Opinion on Drug Safety·Bruno VincenziGiuseppe Tonini
Oct 25, 2016·Oxidative Medicine and Cellular Longevity·Shreesh OjhaMohanraj Rajesh
Jun 11, 2020·Archives of Physiology and Biochemistry·Masoud NajafiMilad Ashrafizadeh
Feb 7, 2020·Environmental Science and Pollution Research International·Mouna MaatoukLeila Chekir Ghedira
May 8, 2020·Oxidative Medicine and Cellular Longevity·Ya-Hong LiuHong-Qi Tian
Oct 8, 2019·Toxicology Research·Tugce BoranBuket Alpertunga
Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong XuYuan-Lu Cui
Dec 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lúcio Ricardo Leite DinizDamião Pergentino de Sousa
Oct 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haibo HuangXiaoqing Miao
Jun 3, 2021·Pharmaceuticals·Pía LorenLuis A Salazar

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
MDA

Software Mentioned

Primer

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.