Molecular and cellular aspects of rhabdovirus entry.

Viruses
Aurélie A V AlbertiniYves Gaudin

Abstract

Rhabdoviruses enter the cell via the endocytic pathway and subsequently fuse with a cellular membrane within the acidic environment of the endosome. Both receptor recognition and membrane fusion are mediated by a single transmembrane viral glycoprotein (G). Fusion is triggered via a low-pH induced structural rearrangement. G is an atypical fusion protein as there is a pH-dependent equilibrium between its pre- and post-fusion conformations. The elucidation of the atomic structures of these two conformations for the vesicular stomatitis virus (VSV) G has revealed that it is different from the previously characterized class I and class II fusion proteins. In this review, the pre- and post-fusion VSV G structures are presented in detail demonstrating that G combines the features of the class I and class II fusion proteins. In addition to these similarities, these G structures also reveal some particularities that expand our understanding of the working of fusion machineries. Combined with data from recent studies that revealed the cellular aspects of the initial stages of rhabdovirus infection, all these data give an integrated view of the entry pathway of rhabdoviruses into their host cell.

References

Apr 1, 1992·Virology·Y GaudinA Flamand
Aug 1, 1991·Journal of Virology·A BenmansourF Lafay
Jan 1, 1986·The Journal of General Virology·F SupertiH Tsiang
Feb 1, 1987·The Journal of General Virology·F SupertiN Orsi
Dec 1, 1986·Brain Research·T L LentzE Hawrot
Apr 1, 1985·Virus Research·T G BurrageA L Smith
Jan 1, 1971·Archiv für die gesamte Virusforschung·L G SchneiderH D Matheka
Jan 1, 1984·Archives of Virology·F SupertiN Orsi
Apr 1, 1983·The Journal of General Virology·M LafonR I Macfarlan
Jan 8, 1982·Science·T L LentzG H Tignor
May 1, 1993·Virology·A FlamandR W Ruigrok
Jan 1, 1995·Annual Review of Physiology·D S McGehee, L W Role
Dec 1, 1996·The Journal of General Virology·F Käsermann, C Kempf
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·C M CarrP S Kim

❮ Previous
Next ❯

Citations

Jun 18, 2016·PloS One·Phonphimon WongthidaAnan Jongkaewwattana
May 19, 2017·Molecular Pharmaceutics·Mira OswaldAchim Goepferich
Mar 30, 2017·Antimicrobial Agents and Chemotherapy·Christine Cruz-OliveiraAndrea T Da Poian
Jan 4, 2013·Journal of Virology·Arun AmmayappanStephen J Russell
Jul 14, 2018·Annual Review of Virology·Gary W Blissard, David A Theilmann
Mar 14, 2018·Nature Communications·Jovan NikolicAurélie A Albertini
Feb 29, 2020·Viruses·Jens H KuhnMatthew Stremlau
May 30, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun LuoXiaofeng Guo
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lijiang LiuDaohong Jiang
Jul 9, 2014·Annual Review of Cell and Developmental Biology·Benjamin Podbilewicz
Jul 28, 2015·Animal Science Journal = Nihon Chikusan Gakkaihō·Katsuo KoshiKazuyoshi Hashizume
Jul 8, 2020·Gene Therapy·Morgane HumbelNicole Déglon
Jun 21, 2014·Genome Announcements·Ana Lucia M WanzellerPedro F C Vasconcelos
Jul 1, 2016·Annual Review of Phytopathology·Andrew O Jackson, Zhenghe Li
Sep 6, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Eduard BaqueroAurélie A Albertini
Nov 1, 2016·Archives of Virology·Renato Mancini AstrayCarlos Augusto Pereira
Jul 8, 2015·Scientific Reports·Haijiao XuHongda Wang
Feb 22, 2014·Viruses·Dawn L WeirChristopher C Broder
Dec 14, 2012·PLoS Neglected Tropical Diseases·Andrea MarziHeinz Feldmann
Mar 5, 2013·Médecine sciences : M/S·Valérie JanelleAlain Lamarre
Nov 20, 2020·Viruses·Alexis Duvergé, Matteo Negroni
Feb 8, 2021·The Nursing Clinics of North America·Sherin F TahmasbiNatasha Tahmasebi
May 10, 2019·Antiviral Research·Zoé LamaCécile Lagaudrière-Gesbert
Oct 2, 2021·Molecular Biotechnology·Mathias MangionBruno Gaillet

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
transfection
X-ray
chemical modification
electron microscopy
GTPase
GTPases
super resolution microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved