Molecular and cellular basis of T cell lineage commitment.

Seminars in Immunology
Rita VicenteNaomi Taylor

Abstract

The thymus forms as an alymphoid thymic primordium with T cell differentiation requiring the seeding of this anlage. This review will focus on the characteristics of the hematopoietic progenitors which colonize the thymus and their subsequent commitment/differentiation, both in mice and men. Within the thymus, the interplay between Notch1 and IL-7 signals is crucial for the orchestration of T cell development, but the precise requirements for these factors in murine and human thympoeisis are not synonymous. Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented.

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Citations

Oct 20, 2012·Nature Immunology·Hidehiro Yamane, William E Paul
Aug 18, 2012·International Immunology·Nahed El-KassarRonald E Gress
Mar 17, 2012·Seminars in Immunology·Changwan HongJung-Hyun Park
Jan 10, 2012·Developmental and Comparative Immunology·Dongyuan MaFeng Liu
Sep 17, 2011·Seminars in Immunology·Tarik Möröy, Cyrus Khandanpour
Jul 27, 2010·Seminars in Immunology·Alfred Singer
Mar 24, 2011·Blood·Werner KrengerGeorg A Holländer
May 10, 2017·Experimental Hematology·Ye ShenH Daniel Lacorazza
Apr 16, 2013·Cellular & Molecular Immunology·Na Niu, Xuebin Qin
Aug 14, 2018·International Immunology·Jastaranpreet Singh, Juan Carlos Zúñiga-Pflücker
Nov 16, 2016·Frontiers in Pediatrics·Susana L Silva, Ana E Sousa
Jul 7, 2017·BMC Immunology·James K PetersonNicholas J C King

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