Molecular and cellular basis of the mammary gland susceptibility to carcinogenesis

Environmental Health Perspectives
J RussoI H Russo

Abstract

Mammary carcinomas induced by the administration of 7,12-dimethylbenz(a)anthracene (DMBA) to young virgin rats arise from undifferentiated terminal ductal structures called terminal end buds (TEBs). TEBs that normally differentiate into alveolar buds (ABs) and lobules under the influence of DMBA develop intraductal proliferations which progress to carcinoma. The high susceptibility of the young virgin rat TEBs to neoplastic transformation is due to its large proliferative compartment, with cells cycling every 10 hr, and to a higher (3)H-DMBA uptake. Progressive differentiation of TEBs into ABs and lobules or their regression to terminal ducts (TDs) is seen with aging. Complete differentiation of the gland is attained only through pregnancy and lactation. The greater differentiation of the gland is manifested as permanent structural changes, consisting in the disappearance of TEBs and in a diminution of the number of TDs due to their differentiation into ABs and lobules. This greater differentiation results in a diminished or total refractoriness of the gland to the carcinogen because ABs and lobules have a lower proliferative compartment and a longer cell cycle than TEBs and TDs. Cells of parous rats have both in vivo and in vi...Continue Reading

References

Dec 28, 1979·Biochemical and Biophysical Research Communications·A Dipple, M E Hayes
Dec 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J Russo, P Wells
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·K Shinohara, P A Cerutti
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S Z Haslam, H A Bern
Sep 1, 1977·Chemico-biological Interactions·R Meneghini, R I Schumacher
Jan 1, 1978·Journal of the National Cancer Institute·D H Janss, T L Ben
Oct 15, 1979·International Journal of Cancer. Journal International Du Cancer·Y N SinhaW P Vanderlaan
Mar 1, 1978·Chemico-biological Interactions·J D ReganD M Jerina
Sep 1, 1978·Cell·D C BennettP S Rudland
Dec 27, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·J W Stirling, J A Chandler
Sep 1, 1977·Journal of the National Cancer Institute·H McGregorG W Beebe
Sep 1, 1977·Journal of the National Cancer Institute·J D Boice, R R Monson
Sep 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P JuretJ C Vernhes
Jan 1, 1975·Annual Review of Biochemistry·C Heidelberger
Feb 15, 1976·International Journal of Cancer. Journal International Du Cancer·B Armstrong
Feb 19, 1972·Lancet·P MorosiniU L Svinhufvud
Apr 26, 1969·Lancet·A P WadeB Haggart
Jul 5, 1969·Lancet·A P WadeC A Clarke
May 1, 1968·The Journal of Clinical Endocrinology and Metabolism·S KumaokaO Takatani
Dec 1, 1969·Cancer·H S Gallager, J E Martin
Aug 1, 1968·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Bresciani
Aug 1, 1974·Gynecologic Oncology·B MacMahon
Apr 1, 1973·Australian and New Zealand Journal of Medicine·P C Bartley
Mar 17, 1972·Nature·N H Sarkar, D H Moore
Nov 1, 1972·Cell and Tissue Kinetics·P Dustin
Mar 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A R BoynsK Griffiths
Mar 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·J A ClemensJ Meites
Nov 1, 1966·Kangogaku zasshi·K Izumio
Dec 1, 1971·Cancer·D E Anderson
Nov 20, 1969·Annals of the New York Academy of Sciences·M Kreimer-BirnbaumP H Pinkerton

❮ Previous
Next ❯

Citations

Apr 25, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Breanne M AndersonDavid W L Ma
Sep 1, 1996·Environmental Health Perspectives·I H Russo, J Russo
Jun 28, 2007·Breast Cancer Research and Treatment·Martha L SlatteryTim Byers
Aug 3, 2010·Environmental Health Perspectives·Angela M BetancourtCoral A Lamartiniere
Aug 2, 2011·Journal of Mammary Gland Biology and Neoplasia·Irma H Russo, Jose Russo
Jul 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J RussoI H Russo
Feb 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Genevieve DallKara Britt
Dec 30, 2014·Frontiers in Endocrinology·Maria BartonJose Russo
Sep 27, 2014·PloS One·Robert A JonesRoger A Moorehead
Sep 28, 2004·Physics in Medicine and Biology·J F DicelloD Huso
May 11, 2017·Endocrine-related Cancer·Yuet-Kin LeungShuk-Mei Ho
Nov 6, 2003·Medicine and Science in Sports and Exercise·Laurie Hoffman-Goetz
Aug 21, 2019·Breast Cancer Research : BCR·Mary Beth TerryUNKNOWN Breast Cancer and the Environment Research Program (BCERP)
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·M HeinrichsD H Hellhammer
Aug 16, 2016·Hormone Molecular Biology and Clinical Investigation·Jose Russo
Jan 16, 2016·Journal of Mammary Gland Biology and Neoplasia·Tanu SharmaChandi C Mandal
Apr 16, 1998·Breast Cancer Research and Treatment·X YangJ M Voigt
Apr 15, 2011·Cancer Science·Naoko HattoriToshikazu Ushijima
Feb 22, 2012·Molecular and Cellular Biochemistry·Ramadass NandhakumarSivasithambaram Niranjali Devaraj
Mar 1, 1985·Journal of Steroid Biochemistry·M O TurrelG L Adessi

❮ Previous
Next ❯

Related Concepts

Related Feeds