Molecular and cellular determinants of motor asymmetry in zebrafish.

Nature Communications
Eric J HorstickHarold A Burgess

Abstract

Asymmetries in motor behavior, such as human hand preference, are observed throughout bilateria. However, neural substrates and developmental signaling pathways that impose underlying functional lateralization on a broadly symmetric nervous system are unknown. Here we report that in the absence of over-riding visual information, zebrafish larvae show intrinsic lateralized motor behavior that is mediated by a cluster of 60 posterior tuberculum (PT) neurons in the forebrain. PT neurons impose motor bias via a projection through the habenular commissure. Acquisition of left/right identity is disrupted by heterozygous mutations in mosaic eyes and mindbomb, genes that regulate Notch signaling. These results define the neuronal substrate for motor asymmetry in a vertebrate and support the idea that haploinsufficiency for genes in a core developmental pathway destabilizes left/right identity.

References

Sep 30, 1977·Annals of the New York Academy of Sciences·W G Webster
May 28, 1990·Behavioural Brain Research·L J Rogers
May 1, 1969·The Journal of Heredity·R L Collins
Aug 22, 1994·The Journal of Comparative Neurology·J D Burrill, S S Easter
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P Barnéoud, H Van der Loos
Aug 15, 1998·Neuropsychologia·P G HepperE A Shannon
Apr 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·I SommerA Bouma
Feb 7, 2003·Development·Joshua T GamseMarnie E Halpern
Feb 13, 2004·Nature·Alberto PascualThomas Préat
Oct 8, 2005·The Behavioral and Brain Sciences·Giorgio Vallortigara, Lesley J Rogers
Mar 31, 2007·The Journal of Comparative Neurology·Michael Hendricks, Suresh Jesuthasan
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Harold A Burgess, Michael Granato
Jul 3, 2007·The Journal of Experimental Biology·Harold A Burgess, Michael Granato
Aug 30, 2008·Behavioural Brain Research·Richard John AndrewValeria Anna Sovrano
Dec 10, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lucilla FacchinMarnie E Halpern
Dec 10, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lesley J Rogers
Jan 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryunosuke AmoHitoshi Okamoto
Feb 16, 2010·Current Biology : CB·Harold A BurgessMichael Granato
Sep 30, 2010·Development·Susana S LopesLeonor Saúde
Mar 12, 2011·Behavioural Brain Research·Cristian Gutiérrez-IbáñezPeter L Hurd
Jan 10, 2012·NeuroImage·Zhong Yi SunJean-François Mangin
Jun 9, 2012·Behavioural Brain Research·Christelle Jozet-AlvesLudovic Dickel
Sep 25, 2012·Current Biology : CB·António M FernandesHarold A Burgess
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tohei YokogawaHarold A Burgess
Apr 12, 2014·Frontiers in Systems Neuroscience·Xiuye Chen, Florian Engert
Apr 16, 2014·Frontiers in Psychology·Tulio GuadalupeClyde Francks
May 23, 2014·Journal of Neurophysiology·Kathryn M TaborHarold A Burgess

❮ Previous
Next ❯

Citations

Feb 5, 2021·Frontiers in Behavioral Neuroscience·William JooSummer B Thyme
Jul 17, 2020·Behavioural Brain Research·Annakarina MundorfNadja Freund

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
RNAseq
PCR
genotyping
whole-genome shotgun sequencing

Software Mentioned

RNAmapper
Imaris
Galaxy
IGVviewer
DAQtimer
ImageJ
bowtie2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.