Molecular and cellular mechanism of glutamate receptors in relation to amyotrophic lateral sclerosis

Current Drug Targets. CNS and Neurological Disorders
Y IwasakiMasao Kinoshita

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder of the central nervous system (CNS) with an unknown etiology. This disorder is characterized clinically by muscular weakness and wasting, and pathologically by selective degeneration of the corticospinal tracts and motor neurons of the brain stem and spinal cord. Median survival following onset is 3 to 5 years. Riluzole, an antiglutamatergic agent has been shown to have modest beneficial effects on survival. Glutamate is the main excitatory neurotransmitter in the CNS and excessive activation of glutamate receptors is excitotoxic to neurons. Glutamate receptor-mediated excitotoxicity has been proposed to explain the pattern of selective neuronal cell death and clinical manifestation of ALS. Activation of glutamate receptors leading to elevation of intracellular calcium may play a major role. This review will focus on the current understanding of the molecular and cellular mechanisms of glutamate receptors in relation to ALS.

Citations

Aug 16, 2006·Neuro-degenerative Diseases·Gilles J GuilleminBruce J Brew
Feb 15, 2005·Clinical Neurology and Neurosurgery·Yasuo IwasakiKen Ikeda
Dec 3, 2015·Surgical Neurology International·Sara ZareiAngel Chinea
Mar 22, 2005·Lancet Neurology·Jennica M C WinhammarMatthew C Kiernan
Apr 23, 2014·Molecular and Cellular Biology·Mridusmita SaikiaMaria Hatzoglou
Feb 28, 2008·Epidemiology·Natalia MorozovaAlberto Ascherio
Dec 13, 2005·Nature Reviews. Drug Discovery·Jia ZhouAlan P Kozikowski

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