PMID: 2484628Jul 1, 1989Paper

Molecular and cellular mechanisms of transformation of C3H/10T1/2 Cl 8 and diploid human fibroblasts by unique carcinogenic, nonmutagenic metal compounds. A review

Biological Trace Element Research
Joseph R Landolph

Abstract

Work from our laboratory showed that carcinogenic metal salts of arsenic, nickel, and chromium induced morphological transformation of cultured C3H/10T1/2 Cl 8 (10T1/2) mouse embryo cells, and that many of the transformants grow in soft agarose and form tumors in nude mice. Concentrations of arsenic, nickel, and chromium compounds that induced morphological transformation did not induce mutation to ouabain resistance in 10T1/2 cells. This indicated that the mechanism of metal induced morphological transformation was likely not caused by induction of base substitution mutations, and in the case of lead chromate, likely not caused by frameshift or deletion mutations. In addition, we showed that carcinogenic arsenic, nickel, and chromium compounds, and MNNG, induced anchorage independence in diploid human fibroblasts. Anchorage-independent cell strains derived from anchorage-independent colonies were stable but did not form foci and eventually senesced, therefore, arsenic and nickel compounds and lead chromate induced stable anchorage independence as an isolated phenotype. Nickel compounds and lead chromate induced anchorage independence but not mutation to ouabain resistance or to 6-thioguanine resistance. Hence, the mechanism of...Continue Reading

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Citations

Aug 4, 2004·Free Radical Biology & Medicine·Tom K Hei, Metka Filipic
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·T K HeiC Waldren
Jul 9, 2004·Critical Reviews in Toxicology·E DoppA V Hirner
Nov 5, 1997·Critical Reviews in Toxicology·M Costa
Nov 24, 2012·Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science·Anita K PatlollaJose A Centeno
Oct 11, 2005·Mutation Research·Anita K Patlolla, Paul B Tchounwou
Jan 1, 2010·Environmental Toxicology and Pharmacology·W LiuP Gallice
Aug 14, 1998·Environmental Health Perspectives·J W HamiltonJ P Lariviere
Oct 31, 2003·Toxicologic Pathology·Paul B TchounwouJose A Centeno
Feb 20, 2007·Chemical Research in Toxicology·Shunchang WangZengliang Yu

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