Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.

Molecular Neurodegeneration
Tiantian GuoYingjun Zhao

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear underlying mechanism. Studies within the last few decades provide growing evidence for a central role of amyloid β (Aβ) and tau, as well as glial contributions to various molecular and cellular pathways in AD pathogenesis. Herein, we review recent progress with respect to Aβ- and tau-associated mechanisms, and discuss glial dysfunction in AD with emphasis on neuronal and glial receptors that mediate Aβ-induced toxicity. We also discuss other critical factors that may affect AD pathogenesis, including genetics, aging, variables related to environment, lifestyle habits, and describe the potential role of apolipoprotein E (APOE), viral and bacterial infection, sleep, and microbiota. Although we have gained much towards understanding various aspects underlying this devastating neurodegenerative disorder, greater commitment towards research in molecular mechanism, diagnostics and treatment will be needed in future AD research.

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 1, 1987·Cell Motility and the Cytoskeleton·S C Papasozomenos, L I Binder
Jun 1, 1989·Neuron·G LeeK S Kosik
Sep 29, 1989·Biochemical and Biophysical Research Communications·G V JohnsonL I Binder
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R C KowalM S Brown
Oct 1, 1989·Journal of Neuroimmunology·S ItagakiD Selkoe
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A ElshourbagyJ M Taylor
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·P LoPrestiL I Binder
Oct 1, 1995·Journal of Neurochemistry·M D LedesmaJ Avila
Oct 1, 1995·European Journal of Biochemistry·L S Yang, H Ksiezak-Reding
Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·S D YanM A Smith
Sep 1, 1993·Journal of Neurochemistry·C X GongK Iqbal
Nov 15, 1996·The Journal of Biological Chemistry·C S ArnoldG W Hart
Jan 1, 1997·Journal of Neuropathology and Experimental Neurology·J J PeiI Grundke-Iqbal
Oct 22, 1998·Neurology·P MecocciU Senin
Mar 14, 2000·Journal of Neuroimmunology·M R WaltonM Dragunow
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·M von BergenE Mandelkow

❮ Previous
Next ❯

Citations

Sep 11, 2020·Cell Death and Differentiation·Dongdong ZhaoYun-Wu Zhang
Oct 20, 2020·ELife·Mitsuru ShinoharaGuojun Bu
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Yuanhui HuoXin Wang
Dec 22, 2020·Frontiers in Aging Neuroscience·Eitan WongYue-Ming Li
Nov 6, 2020·Molecular Neurodegeneration·Zonghua LiGuojun Bu
Dec 17, 2020·International Journal of Molecular Sciences·Daniele LanaMaria Grazia Giovannini
Jan 19, 2021·European Journal of Pharmacology·José María Sánchez MonteroRocío Girón
Mar 9, 2021·Journal of Alzheimer's Disease : JAD·Xu-Long DingPeng Lei
Mar 4, 2021·Biomolecules·Talya ShachamGerardo Z Lederkremer
Mar 18, 2021·Ageing Research Reviews·Tongmei ZhangYouming Lu
Dec 12, 2020·Drug Discovery Today·Shvetank BhattChandragauda R Patil
Apr 4, 2021·International Journal of Molecular Sciences·Susana López-OrtizAlejandro Santos-Lozano
Apr 8, 2021·Metabolic Brain Disease·Bahareh GholamigeravandSara Soleimani Asl
Apr 13, 2021·Cellular and Molecular Life Sciences : CMLS·Donghui ZhuZhen Zhao
Apr 16, 2021·Advances in Pharmacological and Pharmaceutical Sciences·Salim AhammedGolam Sadik
Apr 30, 2021·Expert Review of Neurotherapeutics·Marjan TalebiSaeed Samarghandian
May 1, 2021·International Journal of Molecular Sciences·Stephanie Cristine Hepp RehfeldtMárcia Inês Goettert
May 1, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Alberto Boretti
May 13, 2021·Neuropsychiatric Disease and Treatment·Tamas FulopJacek M Witkowski
May 25, 2021·Journal of Alzheimer's Disease : JAD·Guan-Yong OuWei-Jiang Zhao
Jun 2, 2021·Neurobiology of Aging·Eleni N TsakiriIoannis P Trougakos
Jun 23, 2021·The Journal of Experimental Medicine·Peng XuPaul Greengard
Jun 26, 2021·Neurotoxicity Research·Sedigheh EskandariGholamreza Bahrami
Jun 15, 2021·Chonnam Medical Journal·Hoowon Kim, Ji Yeon Chung
Jul 3, 2021·International Journal of Molecular Sciences·Benita WiatrakKazimierz Gąsiorowski
Jul 3, 2021·International Journal of Molecular Sciences·Grazia Chiellini
Jul 13, 2021·Frontiers in Cellular Neuroscience·Andres Di PaoloJosé Roberto Sotelo-Silveira
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rajib DasMohammad S Mubarak
Jun 15, 2021·Frontiers in Aging Neuroscience·Shaochang WuZongxin Ling
Jul 24, 2021·The Biochemical Journal·Aaron T Balana, Matthew R Pratt
Jul 21, 2021·Molecular Neurodegeneration·Yu-Hui LiuYan-Jiang Wang
Jul 23, 2021·Molecular Neurodegeneration·Eric McDadeRandall J Bateman

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
ubiquitination
polyubiquitination
sumoylation
glycosylation
transgenic
ELISA
histone acetylation

Clinical Trials Mentioned

NCT02256306

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.