Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer

Journal of Cellular Physiology
Maria L MachedaJames D Best

Abstract

Malignant cells are known to have accelerated metabolism, high glucose requirements, and increased glucose uptake. Transport of glucose across the plasma membrane of mammalian cells is the first rate-limiting step for glucose metabolism and is mediated by facilitative glucose transporter (GLUT) proteins. Increased glucose transport in malignant cells has been associated with increased and deregulated expression of glucose transporter proteins, with overexpression of GLUT1 and/or GLUT3 a characteristic feature. Oncogenic transformation of cultured mammalian cells causes a rapid increase of glucose transport and GLUT1 expression via interaction with GLUT1 promoter enhancer elements. In human studies, high levels of GLUT1 expression in tumors have been associated with poor survival. Studies indicate that glucose transport in breast cancer is not fully explained by GLUT1 or GLUT3 expression, suggesting involvement of another glucose transporter. Recently, a novel glucose transporter protein, GLUT12, has been found in breast and prostate cancers. In human breast and prostate tumors and cultured cells, GLUT12 is located intracellularly and at the cell surface. Trafficking of GLUT12 to the plasma membrane could therefore contribute to...Continue Reading

References

May 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I KeydarH J Brenner
Sep 1, 1992·Neurological Research·K IkezakiD P Becker
Mar 13, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·M K Schwartz
Jan 1, 1991·Advances in Enzyme Regulation·E A Newsholme, M Board
Oct 1, 1990·The British Journal of Surgery·E W McDermottN J O'Higgins
Jul 16, 1990·Biochemical and Biophysical Research Communications·T YamamotoH Imura
Mar 1, 1990·Diabetes Care·G I BellS Seino
Jan 1, 1988·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A HennipmanG E Staal
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J BirnbaumO M Rosen
Jan 1, 1987·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A HennipmanG E Staal
Sep 6, 1985·Science·M MuecklerH F Lodish
Apr 29, 1974·Biochimica Et Biophysica Acta·M Hatanaka
Oct 1, 1984·Seminars in Nuclear Medicine·R P Beaney
May 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·S N BirrellW D Tilley
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·S P Zamora-LeónJ C Vera
Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·J OgawaS Koide
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H ShimC V Dang
Oct 31, 1997·Journal of the American Academy of Dermatology·S C BaerM Younes
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·M VeyhlH Koepsell
Jul 9, 1998·Pathology Oncology Research : POR·M Grover-McKayM J Hendrix

❮ Previous
Next ❯

Citations

Mar 31, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Paweł Piątkiewicz, Anna Czech
Oct 31, 2013·Applied Microbiology and Biotechnology·M RehbergU Reichl
Feb 2, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Donna S DorowRodney J Hicks
Jan 16, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Ludwig G StraussAntonia Dimitrakopoulou-Strauss
Mar 3, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ibane AbasoloFrancisco X Real
Feb 23, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Hossein Jadvar
Apr 9, 2011·Pflügers Archiv : European journal of physiology·Rexhep RexhepajFlorian Lang
Apr 10, 2013·Breast Cancer Research and Treatment·Paolo ContieroPaola Muti
Feb 14, 2012·Journal of Bioenergetics and Biomembranes·Simone CardaciMaria Rosa Ciriolo
Sep 15, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Xilin SunXiaoyuan Chen
Oct 6, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alexandru V KorotcovPaul C Wang
Oct 12, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M A KocdorJ Russo
Nov 5, 2008·Annals of Nuclear Medicine·Choichi HoriuchiTomio Inoue
Jan 25, 2012·Pathology Oncology Research : POR·Anna KrzeslakMagdalena Brys
Feb 7, 2013·Journal of Physiology and Biochemistry·Jonai Pujol-GiménezMaria Pilar Lostao
May 27, 2005·Seminars in Cancer Biology·Bryan C Fuchs, Barrie P Bode
Apr 23, 2013·Trends in Endocrinology and Metabolism : TEM·Maria HatziapostolouDimitrios Iliopoulos
Apr 14, 2010·Chemical Reviews·Kristine GlundeZaver M Bhujwalla
Oct 27, 2010·Journal of Medicinal Chemistry·Randal D Goff, Jon S Thorson
Apr 4, 2012·Journal of Medicinal Chemistry·Dasheng WangChing-Shih Chen
Dec 4, 2010·Cell Death and Differentiation·A B HjelmelandJ N Rich
Mar 9, 2013·Cell Death & Disease·Y ZhaoM Tan
Feb 24, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Irem H OzbudakTeri J Franks
May 13, 2009·Nature Reviews. Urology·Hossein Jadvar
Aug 8, 2006·Oncogene·A ChatterjeeD Sidransky
Oct 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Talia HarrisHadassa Degani
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Séverine Loisel-MeyerNaomi Taylor
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Jul 3, 2008·Cancer Biotherapy & Radiopharmaceuticals·Jie LiangLing He
Nov 3, 2009·Cancer Biotherapy & Radiopharmaceuticals·Gilles MeesChristophe Van De Wiele
Mar 2, 2012·Thyroid : Official Journal of the American Thyroid Association·Florian GrabellusSien-Yi Sheu
May 22, 2013·Thyroid : Official Journal of the American Thyroid Association·Min-Hee KimBong-Yun Cha
Mar 27, 2009·Carcinogenesis·Daniel A TennantEyal Gottlieb
Dec 2, 2010·QJM : Monthly Journal of the Association of Physicians·M R Goldstein, L Mascitelli
Aug 24, 2012·Current Opinion in Oncology·Kehinde AdekolaMala Shanmugam
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Philip C CalderPhilip Newsholme

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