Molecular and clinical characterization of PARP9 in gliomas: A potential immunotherapeutic target.

CNS Neuroscience & Therapeutics
Hao XuNanxiang Xiong

Abstract

Glioma is a primary malignancy of the central nervous system (CNS). As biomedicine advances, an efficient molecular target is urgently needed for the diagnosis and treatment of glioma. Meanwhile, several studies have demonstrated that glioma development is closely related to immunity. PARP9 is an inactive mono-ADP-ribosyltransferase belonging to the poly-ADP ribosyltransferase (ARTD) family. In this article, we aimed to reveal the relationship between PARP9 and glioma and explore the potential prognostic value and immunotherapeutic targetability of PARP9 in glioma. PARP9 transcript levels were analyzed with TCGA and GEO databases. The clinicopathological information of patients with glioma in the TCGA database and gene expression profiles were analyzed to determine the relationship between the expression of PARP9 and clinicopathologic characteristics. Kaplan-Meier survival analysis, univariate Cox regression analysis, and multivariate Cox regression analysis were used for survival analysis. Gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) were used for bioinformatics analysis. Correlation analysis explored the relationships between PARP9, infiltrating inflammatory immune cells, and immune checkpoint mo...Continue Reading

References

Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Dec 1, 2006·Annual Review of Immunology·Gabriel A RabinovichEduardo M Sotomayor
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Oct 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea M GriesingerNicholas K Foreman
Nov 7, 2013·JAMA : the Journal of the American Medical Association·Antonio Omuro, Lisa M DeAngelis
May 30, 2014·Methods in Molecular Biology·Maria A DoyleStephen Q Wong
Nov 5, 2014·Current Opinion in Neurology·Adelheid WoehrerJill S Barnholtz-Sloan
Apr 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott N GettingerJulie R Brahmer
Jul 29, 2015·Brain, Behavior, and Immunity·Patrícia DominguesMaría Dolores Tabernero
Mar 16, 2016·Nature Reviews. Clinical Oncology·Diana Romero
Jul 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer E KimMichael Lim
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Oct 21, 2016·Oncotarget·Xuhao ZhangJingtao Chen
Nov 1, 2016·Nature Communications·Hiroshi IwataMasanori Aikawa
Jan 25, 2017·Nature Reviews. Clinical Oncology·Alberto MantovaniPaola Allavena
Mar 14, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anna GieryngBozena Kaminska
Apr 19, 2017·Nature Reviews. Cancer·Qingfei JiangCatriona H M Jamieson
May 26, 2017·Frontiers in Pharmacology·Jing HuangJindong Chen
Jul 29, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lijie ZhaiDerek A Wainwright
Apr 7, 2018·Cell
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Elisa PeranzoniEmmanuel Donnadieu
Apr 17, 2018·The New England Journal of Medicine·Leena GandhiUNKNOWN KEYNOTE-189 Investigators

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE50161
18
GPL570

Clinical Trials Mentioned

NCT02526017

Software Mentioned

GSVA
GSEA
GraphPad Prism
R
SPSS

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.