Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan.

Antimicrobial Agents and Chemotherapy
Yi-Tsung LinLiang Chen

Abstract

Hypervirulent Klebsiella pneumoniae strains are the major cause of liver abscesses throughout East Asia, and these strains are usually antibiotic susceptible. Recently, multidrug-resistant and hypervirulent (MDR-HV) K. pneumoniae strains have emerged due to hypervirulent strains acquiring antimicrobial resistance determinants or the transfer of a virulence plasmid into a classic MDR strain. In this study, we characterized the clinical and microbiological properties of K. pneumoniae liver abscess (KPLA) caused by MDR-HV strains in Taiwan. Patients with community onset KPLA were retrospectively identified at Taipei Veterans General Hospital during January 2013 to May 2018. Antimicrobial resistance mechanisms, capsular types, and sequence types were determined. MDR-HV strains and their parental antimicrobial-susceptible strains further underwent whole-genome sequencing (WGS) and in vivo mice lethality tests. Thirteen MDR-HV strains were identified from a total of 218 KPLA episodes. MDR-HV strains resulted in similar outcomes to antimicrobial-susceptible strains. All MDR-HV strains were traditional hypervirulent clones carrying virulence capsular types. The major resistance mechanisms were the overexpression of efflux pumps and/or ...Continue Reading

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Citations

Aug 4, 2020·International Journal of Antimicrobial Agents·Chien ChuangYi-Tsung Lin
Feb 10, 2021·Infection and Immunity·Shekina Gonzalez-FerrerDaria Van Tyne
Apr 18, 2021·International Journal of Antimicrobial Agents·Po-Han HuangYi-Tsung Lin
Oct 25, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takeaki WajimaHidemasa Nakaminami

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