PMID: 8597859Sep 1, 1995Paper

Molecular and cytogenetic analysis of a cerebellar primitive neuroectodermal tumor with prominent neuronal differentiation: detection of MYCN amplification by differential polymerase chain reaction and Southern blot analysis

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
V JayR Humphreys

Abstract

Oncogene amplification is uncommon in cerebellar primitive neuroectodermal tumor (medulloblastoma) and its frequency and diversity are greater in medulloblastoma cell lines. We describe a medulloblastoma in a 10-year-old-girl with striking neuronal differentiation evident in the islands of ganglion cells intermixed with more primitive undifferentiated cells. The islands of ganglion cells showed prominent synaptophysin positivity. Karyotypic analysis revealed hypo- and hyperdiploidy with multiple random rearrangements and double minute chromosomes. Differential polymerase chain reaction and Southern blot analysis revealed up to 25-fold MYCN amplification.

References

Nov 1, 1989·Genes, Chromosomes & Cancer·J A BiegelB S Emanuel
Jun 1, 1989·Journal of Neurosurgery·M FujimotoJ L Story
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L W StantonJ M Bishop
Jan 1, 1988·Cancer Genetics and Cytogenetics·S H BignerD D Bigner
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M SchwabJ M Bishop
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Citations

Jul 1, 1996·Journal of Neuro-oncology·J P Provias, L E Becker
May 26, 2007·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Syed Ali Jaffar KazmiCheryl Ann Palmer

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