Molecular and cytogenetic characterization of highly repeated DNA sequences in the vole Microtus cabrerae

Heredity
R FernándezA Sánchez

Abstract

The genus Microtus presents several species with extremely large sex chromosomes that contain large blocks of constitutive heterochromatin. Several cytogenetic and molecular studies of the repetitive sequences in species of the genus Microtus have demonstrated that the heterochromatin is highly heterogeneous. We have cloned and characterized a family of repetitive DNA sequences from M. cabrerae, a species with large heterochromatic blocks on the giant sex chromosomes. These repetitive sequences are 65.84% A-T rich, organized in tandem, with a 161-bp unit and are located on the centromeric region of autosomes and the X chromosome. In addition, this repetitive DNA is located throughout the entire heterochromatic block of the X chromosome and on three interstitial bands in the heterochromatic block of the Y chromosome. Comparative analysis of this family of repetitive sequences from three Microtus species revealed that the development of these sequences has occurred by concerted evolution. Our results support the hypothesis that the heterochromatic blocks from the sex chromosomes of different species are evolving independently and they probably have the genetic capacity to amplify and retain different satellite DNAs. For a topic r...Continue Reading

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Citations

Feb 11, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·J A MarchalA Sánchez
Feb 11, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·J A MarchalA Sánchez
Mar 18, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·J A MarchalA Sánchez
Jun 7, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Gustavo C S KuhnFabio M Sene
Oct 7, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·M J AcostaA Sánchez
Oct 8, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·M Th RovatsosAntonio Sánchez
May 30, 2002·Genome Génome / Conseil National De Recherches Canada·Rosa FernándezAntonio Sánchez
May 2, 2003·Genome Génome / Conseil National De Recherches Canada·José Gallin, Alfried P Vogler
Sep 23, 2014·Integrative Zoology·Gloria Cuenca-BescósJacint Ventura
Dec 21, 2014·Chromosoma·I Romero-FernándezJ A Marchal
Aug 19, 2003·Hereditas·Belen Megías-NogalesAntonio Sánchez
Mar 29, 2016·Journal of Genetics·A Vieira-da-SilvaR Chaves
Mar 16, 2019·Epigenetics & Chromatin·Kathrin S HeinzM Cristina Cardoso

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