Molecular and developmental genetics of the Punch locus, a pterin biosynthesis gene in Drosophila melanogaster

Developmental Genetics
J M O'DonnellE R Reynolds


Punch (Pu), the gene encoding the pterin biosynthetic enzyme GTP cyclohydrolase in Drosophila, is a complex locus. Mutations fall into several complementation classes that correspond to classes of mutants with distinct morphological and protein phenotypes. Two of these classes are developmentally specific, with mutants in each having defects in discrete subsets of the known functions of the locus. Defined functions of the locus include a role in embryonic nuclear divisions using initially a maternal Pu product, the synthesis of pterin cofactors that are required for catecholamine biosynthesis beginning in late embryogenesis, and the production of pterin-screening pigments in the developing adult eye. Mutant phenotypes include an interruption in synchronous nuclear divisions in precellular blastoderm embryos, a segment pattern phenotype in late embryos, failure to pigment and cross-link embryonic cuticular structures and failure to synthesize red eye pigments. Molecular analysis reveals that the locus is large, a minimum of 29 kb as defined by Southern mapping of Pu mutants. This region is transcriptionally extremely active, encoding at least 16 developmentally regulated transcripts. One transcript has been shown to be responsib...Continue Reading


Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·E M MaineT W Cline
Oct 1, 1987·Developmental Biology·E R Reynolds, J M O'Donnell
Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·J NewportD Forbes
Jun 1, 1985·Die Naturwissenschaften·I ZieglerW J Müller
Jan 1, 1981·Journal of Inherited Metabolic Disease·J L DhondtP Ardouin
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P J Van HaastertT M Konijn
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J L JohnsonS K Wadman

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