Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts

Circulation Journal : Official Journal of the Japanese Circulation Society
Seiji HatanoLong-Tai Fu

Abstract

Many pathological conditions induce electrical remodeling, possibly through intracellular Ca2+ overload, but the currently available L-type Ca2+ channel blockers may be detrimental because of their global negative inotropic effects. To determine whether the L-type Ca2+ channel is identical throughout the heart, the distribution of the mRNAs and proteins comprising the L-type Ca2+ channel and its electrophysiological properties were analyzed in rat atria and ventricles. The mRNA of alpha2delta-2 (Cacna2d2) was more abundantly expressed in the atrium (approximately 5-fold) than in the ventricle. In contrast, alpha1C (Cacna1c) (Cav1.2) mRNA was significantly less abundant in the atrium. The level of the alpha1C (Cacna1c) (Cav1.2) protein was decreased (approximately 0.5-fold) and that of alpha2 delta-1 (Cacna2d1) was increased (approximately 2-fold) in the atrium compared with the ventricle. Although the peak ICa,L density showed no significant differences, voltage dependence of inactivation and activation of the current showed a more depolarized shift in the atrium than in the ventricle. These results indicate that in the rat heart the L-type Ca2+ channel differs between the atrium and ventricle with regard to gene expression and...Continue Reading

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Citations

Jun 1, 2013·Annals of Biomedical Engineering·Michelangelo PaciStefano Severi
Nov 21, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yumiko WatanabeYutaka Imai
Oct 18, 2016·Heart, Lung & Circulation·Yuejuan CaoZhaozeng Guo
Oct 22, 2014·Circulation Research·Jessica L CaldwellAndrew W Trafford
Dec 21, 2007·The Journal of Comparative Neurology·Mengliang ZhangHans Hultborn
Sep 23, 2010·Physiological Genomics·Ruben S R M MartherusTorik A Y Ayoubi
Aug 28, 2020·The Journal of Experimental Biology·Tatiana S FilatovaHolly A Shiels

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