Molecular and genetic interactions of the RNA degradation machineries in Firmicute bacteria

Wiley Interdisciplinary Reviews. RNA
Peter Redder

Abstract

Correct balance between bacterial RNA degradation and synthesis is essential for controlling expression level of all RNAs. The RNA polymerase, which performs the RNA synthesis, is highly conserved across the bacterial domain. However, this is surprisingly not the case for the RNA degradation machinery, which is composed of different subunits and performs different enzymatic reactions, depending on the organism. In Escherichia coli, the RNA decay is performed by the degradosome complex, which forms around the membrane-associated endoribonuclease RNase E, and is stable enough to be purified without falling apart. In contrast, many Firmicutes, for example, Bacillus subtilis, Staphylococcus aureus, and Streptococcus pneumoniae, do not encode an RNase E homolog, but instead have the endoribonuclease RNase Y and the exo- and endo-ribonuclease RNase J complex. A wide range of experiments have been performed, mainly with B. subtilis and S. aureus, to determine which interactions exist between the various RNA decay enzymes in the Firmicutes, with the goal of understanding how RNA degradation (and thus gene expression homeostasis and regulation) is organized in these organisms. The in vivo and in vitro data is diverse, and does not alway...Continue Reading

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Citations

Feb 20, 2020·MBio·Lina HamoucheHarald Putzer
Apr 1, 2021·Nucleic Acids Research·Soumaya LaalamiHarald Putzer
Nov 5, 2019·Trends in Biochemical Sciences·Alejandro Tejada-ArranzHilde de Reuse
Aug 28, 2021·Frontiers in Microbiology·Brice Felden, Yoann Augagneur

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