PMID: 9420284Jan 7, 1998Paper

Molecular and immunophenotypical characterization of a feline immunodeficiency virus (FIV)-associated lymphoma: a direct role for FIV in B-lymphocyte transformation?

Journal of Virology
J A BeattyJ Neil

Abstract

We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.

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Citations

Apr 2, 2016·ILAR Journal·Sarah KayeHelle Bielefeldt-Ohmann
Jul 21, 2005·New Zealand Veterinary Journal·R A Squires
Feb 16, 2007·Australian Veterinary Journal·M J Hosie, J A Beatty
Feb 16, 2010·Journal of the American Veterinary Medical Association·Joanna D WhiteNicholas Malikides
Jul 7, 2009·The Journal of Veterinary Medical Science·Kaori IdeHajime Tsujimoto
Oct 16, 2001·Australian Veterinary Journal·L J GaborP J Canfield
May 3, 2002·Clinical and Diagnostic Laboratory Immunology·Chadd E Nesbit, Stanley A Schwartz
Dec 4, 2012·Viruses·Katrin Hartmann
Aug 9, 2020·Frontiers in Veterinary Science·Diana Giannuzzi, Luca Aresu
Jan 1, 1999·Alternatives to Laboratory Animals : ATLA·S J Gray

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