Abstract
We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.
References
Apr 4, 1992·The Veterinary Record·J J CallananO Jarrett
Dec 1, 1992·Veterinary Immunology and Immunopathology·J J CallananO Jarrett
Oct 1, 1992·European Journal of Immunology·D Y MasonJ J van Dongen
Sep 1, 1992·Microbiological Reviews·B R Cullen
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J Laurence, S M Astrin
Jan 1, 1991·Intervirology·J K YamamotoT Okuda
Oct 1, 1990·Journal of Virology·T R PhillipsJ H Elder
Aug 1, 1991·The Journal of Pathology·A D RamsayM P Cranage
Jan 1, 1989·Archives of Virology·T MiyazawaT Mikami
Apr 2, 1984·Nature·J C NeilO Jarrett
Mar 1, 1995·Journal of Clinical Immunology·J G Monroe, L E Silberstein
Apr 10, 1995·International Journal of Cancer. Journal International Du Cancer·A TerryJ C Neil
May 1, 1994·Journal of Comparative Pathology·A PoliM Bendinelli
Aug 1, 1994·AIDS·B G HerndierM S McGrath
Dec 1, 1994·The Journal of General Virology·R OsborneO Jarrett
Feb 1, 1994·Immunological Reviews·D Tarlinton
Sep 1, 1994·The Journal of Infectious Diseases·R V EnglishM B Tompkins
Mar 1, 1993·The Journal of General Virology·M A RigbyJ C Neil
May 1, 1996·Veterinary Pathology·J J CallananO Jarrett
Aug 1, 1996·Journal of Virology·G A DeanN C Pedersen
Citations
Apr 2, 2016·ILAR Journal·Sarah KayeHelle Bielefeldt-Ohmann
Jul 21, 2005·New Zealand Veterinary Journal·R A Squires
Feb 16, 2007·Australian Veterinary Journal·M J Hosie, J A Beatty
Feb 16, 2010·Journal of the American Veterinary Medical Association·Joanna D WhiteNicholas Malikides
Feb 20, 2010·Retrovirology·A Katrin Helfer-HungerbuehlerRegina Hofmann-Lehmann
Jul 7, 2009·The Journal of Veterinary Medical Science·Kaori IdeHajime Tsujimoto
Oct 16, 2001·Australian Veterinary Journal·L J GaborP J Canfield
Feb 28, 2001·Australian Veterinary Journal·J WangW F Robinson
May 3, 2002·Clinical and Diagnostic Laboratory Immunology·Chadd E Nesbit, Stanley A Schwartz
Dec 4, 2012·Viruses·Katrin Hartmann
Aug 9, 2020·Frontiers in Veterinary Science·Diana Giannuzzi, Luca Aresu
Jan 1, 1999·Alternatives to Laboratory Animals : ATLA·S J Gray
May 16, 2000·The Veterinary Record·D D AddieO Jarrett
May 26, 2018·Viruses·Brian G MurphyPeter Moore
Sep 5, 2001·Virology·T MizunoH Tsujimoto