PMID: 11315626Apr 24, 2001Paper

Molecular and kinetic features of transitional cell carcinomas of the bladder: biological and clinical implications

Virchows Archiv : an International Journal of Pathology
S I BaithunSalvador J Diaz-Cano

Abstract

Molecular and kinetic analyses have contributed to our understanding of the biology of transitional cell carcinomas (TCC) of the bladder. The concordant pattern of X-chromosome inactivation of multiple TCCs appearing at different times and at different sites and concordant genetic abnormalities in a subset of muscle-invasive TCC strongly support a monoclonal origin and a homogeneous tumor cell selection throughout the neoplasm. However, topographic intratumor heterogeneity results from the accumulation of genetic lesions in tumor suppressor genes, predominantly neurofibromatosis (NF)-1-defective in the superficial compartment and tumor protein p53 (TP53)-defective in the deep one, with lower proliferation and down-regulation of apoptosis in the latter. TCCs follow the general concept of multistep carcinogenesis and proceed through two distinct genetic pathways responsible for generating different TCC morphologies. These are the inactivation of cyclin-dependent kinase inhibitors (p15, p16, and p21WAF/CIP1) in low-grade TCC and early TP53-mediated abnormalities in high-grade TCC. TCC progression correlates with genetic instability and accumulation of collaborative genetic lesions mainly involving TP53, retinoblastoma (RB)-1, and ...Continue Reading

Citations

Feb 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ehab A HusainSalvador J Diaz-Cano
Jun 8, 2013·World Journal of Gastroenterology : WJG·Athanasios Xanthoulis, Dina G Tiniakos
Apr 22, 2015·International Journal of Molecular Sciences·Salvador J Diaz-Cano
Jan 18, 2003·International Journal of Cancer. Journal International Du Cancer·Shigeru SakanoPer Larsson
Feb 7, 2009·Gan to kagaku ryoho. Cancer & chemotherapy·Nobuo Shinohara
Oct 11, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P K Tsantoulis, V G Gorgoulis
Mar 13, 2012·International Journal of Molecular Sciences·Salvador J Diaz-Cano
Jan 16, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Francesca SanguedolceLuigi Cormio

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