Abstract
Body cavity-based lymphoma, also known as primary effusion lymphoma, is a newly recognized acquired immunodeficiency syndrome (AIDS)-related lymphoma that has been linked to the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). To date, direct visualization of the virus in a clinical sample has not been demonstrated. We have performed an extensive clinical, histologic, immunophenotypic, ultrastructural, and molecular genetic correlative study on multiple tissue samples obtained premortem and at autopsy from an patient with AIDS with Kaposi's sarcoma and body cavity-based lymphomas. We demonstrate the presence of human herpesvirus-8 in a primary clinical sample at the ultrastructural and molecular level, as well as document multiple lymphomatous tumor masses at autopsy.
References
Apr 6, 1991·Lancet·V BeralH Jaffe
Jan 1, 1992·The Medical Clinics of North America·A M Levine
Aug 1, 1990·American Journal of Clinical Pathology·A E WaltsJ W Said
Jul 10, 1987·Science·M S LeeS A Stass
Dec 1, 1995·Nature Medicine·C BoshoffJ J O'Leary
Oct 5, 1995·The New England Journal of Medicine·R G NadorJ W Said
May 4, 1995·The New England Journal of Medicine·P S Moore, Y Chang
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
May 4, 1995·The New England Journal of Medicine·B Roizman
Dec 16, 1994·Science·Y ChangP S Moore
Dec 1, 1994·Human Pathology·G H SegalR C Braylan
Aug 1, 1994·Virology·A Apolloni, T B Sculley
Feb 1, 1993·Histochemistry·A A LongH J Wolfe
Jan 1, 1993·American Journal of Epidemiology·P ReynoldsG F Lemp
Feb 1, 1996·American Journal of Clinical Pathology·M Q AnsariR W McKenna
Mar 1, 1996·Nature Medicine·R RenneD Ganem
May 1, 1996·The Journal of Experimental Medicine·E A MesriA S Asch
Nov 1, 1996·Journal of Virology·E CesarmanD M Knowles
Dec 6, 1996·Science·P S MooreY Chang
Jan 1, 1997·Journal of Virology·F NeipelB Fleckenstein
Jan 16, 1997·The New England Journal of Medicine·K E ForemanG J Nabel
Mar 1, 1997·Journal of Virology·M LiJ U Jung
Citations
Sep 10, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul E WakelyGerard J Nuovo
Feb 14, 2002·British Journal of Haematology·Kathleen S WilsonNancy R Schneider
Aug 13, 1998·The New England Journal of Medicine·D JonesJ C Aster
Jan 9, 1999·The New England Journal of Medicine·J M Orenstein, B Herndier
Jan 25, 2003·Current Opinion in Pediatrics·Hal B Jenson
Oct 19, 2004·The American Journal of Surgical Pathology·Amy ChadburnDaniel M Knowles
Dec 1, 2006·Acta Haematologica·Yutaka KobayashiMasafumi Taniwaki
Oct 31, 2009·CytoJournal·Fadi BrimoManon Auger
Oct 29, 2010·Annals of Thoracic Medicine·Carolyn M AllenAli Nawaz Khan
Aug 1, 2013·Archives of Pathology & Laboratory Medicine·Sanjay Patel, Philip Xiao
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M TeitellR Wall
Dec 13, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J C LeaoC Scully
Sep 15, 1998·The American Journal of Pathology·K E ForemanB J Nickoloff
Mar 3, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rajiv M PatelEric D Hsi
Jun 8, 2007·Cancer·Fadi BrimoManon Auger
Dec 25, 2010·Acta Microbiologica Et Immunologica Hungarica·J RajčániS Szathmary
Feb 17, 2001·The Journal of Pathology·V AscoliF Lo-Coco
Jun 14, 2017·AIDS·Priscila H GonçalvesRobert Yarchoan
Sep 10, 2002·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Marco GessiRiccardo Ricci
Nov 9, 2000·Ultrastructural Pathology·A TinariF Superti
Nov 9, 2000·Ultrastructural Pathology·J M OrensteinG S Hayward