Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster

Nature
T F Mackay, C H Langley

Abstract

Variation in quantitative characters underlies much adaptive evolution and provides the basis for selective improvement of domestic species, yet the genetic nature of quantitative variation is poorly understood. Many loci affecting quantitative traits have been identified by the segregation of mutant alleles with major qualitative effects. These alleles may represent an extreme of a continuum of allelic effects, and most quantitative variation could result from the segregation of alleles with subtle effects at loci identified by alleles with major effects. The achaete-scute complex in Drosophila melanogaster plays a central part in bristle development and has been characterized at the molecular level. The hypothesis that naturally occurring quantitative variation in bristle number could be associated with wild-type alleles of achaete-scute was tested by correlating phenotypic variation in bristle number with molecular variation in restriction maps in this region among chromosomes extracted from natural populations. DNA insertion variation in the achaete-scute region was found to be strongly associated with variation in bristle number.

References

Dec 25, 1975·Nature·J N Thompson
Jul 1, 1990·Trends in Genetics : TIG·D Hartley, R White
Aug 1, 1989·Trends in Genetics : TIG·A Ghysen, C Dambly-Chaudiere
Dec 1, 1987·Genes & Development·M Ruiz-Gómez, J Modolell
May 1, 1988·Genes & Development·A Ghysen, C Dambly-Chaudière

❮ Previous
Next ❯

Citations

Nov 20, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M D Purugganan
Feb 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T F Mackay
May 23, 1996·Molecular & General Genetics : MGG·A Domínguez, J Albornoz
May 11, 2005·Genetica·Patrick C Phillips
Nov 24, 2001·Mechanisms of Ageing and Development·Trudy F C Mackay
Aug 1, 1995·Trends in Ecology & Evolution·T Mitchell-Olds
Jun 14, 2001·Trends in Ecology & Evolution·H Allen Orr
Oct 26, 2000·Molecular Ecology·M D Purugganan
Jul 26, 2013·Molecular Biology and Evolution·Julie M CridlandKevin R Thornton
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Ohta
Aug 20, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Trudy F Mackay, Richard F Lyman
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Trudy F C Mackay
May 5, 2009·Genome Research·Jonathan Flint, Trudy F C Mackay
Sep 27, 2000·Evolution; International Journal of Organic Evolution·D L Stern
Jul 28, 2001·Evolution; International Journal of Organic Evolution·E S Haag, J R True
Dec 9, 2000·Annual Review of Entomology·W C BlackN M DuTeau
Nov 10, 2001·Annual Review of Genomics and Human Genetics·M E ZwickA Chakravarti
Jul 13, 2011·International Journal of Molecular Sciences·Heather Kirk, Joanna R Freeland
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·S V NuzhdinT F Mackay
Feb 13, 2001·Gene·J H Gillespie
Jul 15, 2003·The American Naturalist·Joachim HermissonGünter P Wagner
Sep 17, 2015·Evolution; International Journal of Organic Evolution·David L Remington
Sep 13, 2005·Evolution; International Journal of Organic Evolution·Ian Dworkin
Mar 1, 2005·Evolution & Development·Patrícia BeldadeAnthony D Long
Sep 25, 2003·Evolution; International Journal of Organic Evolution·Xu-Sheng Zhang, William G Hill
Jul 3, 2004·Trends in Plant Science·David B Neale, Outi Savolainen
Nov 9, 2001·Annual Review of Genetics·T F Mackay
May 1, 1995·Current Biology : CB·P D Keightley
Dec 19, 2013·PloS One·Evan KochMark Kirkpatrick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.