Molecular and phylogenetic analyses of bovine rhinovirus type 2 shows it is closely related to foot-and-mouth disease virus

Virology
Jason HollisterElizabeth Rieder

Abstract

Bovine rhinovirus 2 (BRV2), a causative agent of respiratory disease in cattle, is tentatively assigned to the genus Rhinovirus in the family Picornaviridae. A nearly full-length cDNA of the BRV2 genome was cloned and the nucleotide sequence determined. BRV2 possesses a putative leader proteinase, a small 2A protein and a poly(C) tract, which are characteristic of aphthoviruses. Alignment of BRV-2 and FMDV polyproteins showed that 41% of amino acids were identical within the P1 region. Furthermore, 2A, 2C, 3B(3), 3C and 3D proteins are as much as 67%, 52%, 52%, 50%, and 64% identical, respectively. BRV2 leader protein is rapidly released from the viral polyprotein and cleaves eIF4G at a rate similar to FMDV leader proteinase, suggesting a functional relationship between the leader protein in these viruses. The results suggest that BRV2 is closely related to FMDV and should therefore be considered as a new species within the genus Aphthovirus.

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Citations

Dec 4, 2012·Neurosurgical Focus·Louis De BeaumontNadia Gosselin
Jan 27, 2015·Virus Research·Encarnación Martínez-SalasRosa Diaz-Toledano
Aug 12, 2008·Virus Research·Olga Fernández-MiragallEncarnación Martínez-Salas
Jan 15, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xueqing MaZaixin Liu
Sep 4, 2012·International Journal of Molecular Sciences·Devendra K Rai, Elizabeth Rieder
Jan 4, 2017·Veterinary Microbiology·Fayna Diaz-San SegundoTeresa de Los Santos
Mar 16, 2018·Current Opinion in Virology·Teresa de Los SantosLuis L Rodriguez
Aug 5, 2021·PLoS Pathogens·Velia PenzaAutumn J Schulze

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