Molecular and serological evidence for the circulation of the tick symbiont Midichloria (Rickettsiales: Midichloriaceae) in different mammalian species

Parasites & Vectors
Chiara BazzocchiSara Epis

Abstract

The Midichloriaceae is a novel family of the order Rickettsiales, that encompasses intracellular bacteria associated with hard ticks (Ixodidae) and other arthropods. The most intensively investigated member of this family is Midichloria mitochondrii, a symbiotic bacterium of the sheep tick Ixodes ricinus, characterized by the capacity of multiplying inside the mitochondria. A recent study suggested that these bacteria might be inoculated into the human host during the tick bite. The purpose of this study was to determine the potential infectivity of Midichloria bacteria for non-human animals exposed to the risk of tick bite. Blood from horses, cattle, sheep and dogs exposed to the risk of tick bite was included in this study. DNAs were extracted, and amplified using 16S ribosomal RNA primers conserved in the Midichloria genus. Furthermore, sera from dogs exposed to the risk of tick bite were analyzed in order to evaluate the presence of antibodies against the recombinant flagellar protein (rFliD) from M. mitochondrii using an ELISA test. Here we present two lines of evidence that support the possibility that bacteria from the genus Midichloria are inoculated into vertebrate hosts during a tick bite: (i) a direct evidence, i.e. ...Continue Reading

References

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Citations

Nov 28, 2015·Experimental & Applied Acarology·Radek KlubalJan Hubert
May 6, 2015·Trends in Parasitology·Sukanya Narasimhan, Erol Fikrig
Mar 18, 2016·PLoS Neglected Tropical Diseases·Sara MoutaillerMuriel Vayssier-Taussat
Mar 2, 2017·PLoS Neglected Tropical Diseases·Sarah I BonnetEvelyne Le Naour
Dec 2, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·K KubiakE Dzika
Aug 28, 2018·PloS One·Francesco CeruttiSimone Peletto
Mar 19, 2020·Cellular Microbiology·Fabrizia StavruDavide Sassera
Oct 25, 2017·Antonie van Leeuwenhoek·Sándor HornokRegina Hofmann-Lehmann
Jun 24, 2017·Frontiers in Cellular and Infection Microbiology·Sarah I BonnetOlivier Duron
Feb 25, 2017·Frontiers in Microbiology·Kassandra E ZailaWei-Jen Chang
Aug 30, 2019·Transboundary and Emerging Diseases·Timon FischerArd M Nijhof
Dec 15, 2020·Parasite Immunology·Sarah Irène Bonnet, Thomas Pollet
Sep 23, 2019·Ticks and Tick-borne Diseases·Alaa M Al-KhafajiBenjamin L Makepeace
Sep 7, 2021·Transboundary and Emerging Diseases·Giovanni SgroiDomenico Otranto

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

MUSCLE
Blast
SeaView

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