Molecular and supramolecular structural studies on significant repetitive sequences of resilin

Chembiochem : a European Journal of Chemical Biology
Antonio M TamburroAntonietta Pepe

Abstract

Resilin is a member of the family of elastomeric proteins and is found in specialised regions of the cuticle of most insects, and provides low stiffness, high strain and efficient energy storage. It is best known for its role in insect flight and the remarkable jumping ability of fleas and spittle bugs. In common with other elastomeric proteins, the recently identified Drosophila melanogaster proresilin shows glycine-rich repetitive sequences; in particular the N- and C-terminal regions of the protein are dominated by 18 repeats of a 15-residue sequence (SDTYGAPGGGNGGRP) and eleven repeats of a 13-residue sequence (GYSGGRPGGQDLG), respectively. We synthesised and analysed the molecular and supramolecular structure of some polypeptides with sequences belonging to the glycine-rich repeated domain of D. melanogaster resilin. The conformational studies performed by CD, FTIR and NMR spectroscopies pointed to the coexistence of two main conformational features, such as folded beta-turns and (quasi)extended structures (e.g., poly-L-proline II conformation) in common with other elastomeric proteins; this suggests an elasticity mechanism for resilin common to other elastomeric proteins. Our data show that also in the case of resilin, re...Continue Reading

References

Jun 24, 1991·Biochimica Et Biophysica Acta·M Jackson, H H Mantsch
Jun 1, 1966·Journal of Insect Physiology·G C Coles
Dec 1, 1994·Protein Science : a Publication of the Protein Society·E G Hutchinson, J M Thornton
Mar 1, 1993·International Journal of Peptide and Protein Research·A PerczelG D Fasman
Nov 1, 1995·Journal of Biomolecular NMR·F DelaglioA Bax
Feb 28, 1998·Current Biology : CB·Q CaoH Bayley
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·L Debelle, A M Tamburro
Nov 21, 2000·Trends in Biochemical Sciences·A S Tatham, P R Shewry
Aug 3, 2001·Insect Biochemistry and Molecular Biology·D H Ardell, S O Andersen
Aug 22, 2001·Biochimica Et Biophysica Acta·A S TathamD W Urry
Mar 26, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John GoslineKen Savage
Jan 2, 2003·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Kenji Tonan, Shun-ichi Ikawa
Apr 15, 1961·Biochimica Et Biophysica Acta·K BAILEY, T WEIS-FOGH
Oct 9, 1964·Biochimica Et Biophysica Acta·S O ANDERSEN
Dec 4, 2003·Expert Opinion on Biological Therapy·Gerd Kochendoerfer
Jun 11, 2005·Macromolecular Bioscience·Brigida BochicchioAntonio M Tamburro
Oct 14, 2005·Nature·Christopher M ElvinNicholas E Dixon
Jul 5, 2006·Cellular and Molecular Life Sciences : CMLS·X HuC A Vierra
Jan 16, 2007·Protein Engineering, Design & Selection : PEDS·Russell E LyonsChristopher M Elvin
Nov 6, 2007·The Journal of Experimental Biology·Henry Bennet-Clark
May 13, 2008·The International Journal of Biochemistry & Cell Biology·Steven G Wise, Anthony S Weiss
Jun 3, 2008·The Journal of Experimental Biology·Ken N Savage, John M Gosline
Jul 1, 2008·Biophysical Journal·Kate M NairnChristopher M Elvin
Jan 1, 2009·Soft Matter·Manoj B CharatiKristi L Kiick

❮ Previous
Next ❯

Citations

Jul 9, 2013·Acta Biomaterialia·Renay S-C SuJulie C Liu
Jul 16, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Jasmin L WhittakerNamita Roy Choudhury
Jul 15, 2015·Advanced Healthcare Materials·Alessandra GirottiJosé Carlos Rodríguez-Cabello
Apr 4, 2018·Journal of Biomedical Materials Research. Part a·Linqing LiKristi L Kiick
Jun 4, 2011·Journal of Polymer Science. Part A, Polymer Chemistry·Linqing LiKristi L Kiick
Dec 3, 2011·Chirality·Brigida Bochicchio, Antonietta Pepe
Aug 25, 2012·Bioinspiration & Biomimetics·F SbranaM Vassalli
Aug 21, 2013·Macromolecules·Christopher L McGannKristi L Kiick
Jul 13, 2016·Chirality·Brigida BochicchioAntonietta Pepe
Sep 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rajkamal BaluNamita R Choudhury
Nov 20, 2019·Nanomaterials·Angelo BracalelloChiara Battocchio
Mar 9, 2019·Frontiers in Chemistry·Abdon Pena-Francesch, Melik C Demirel
Jun 9, 2017·Annual Review of Chemical and Biomolecular Engineering·Yun Jung YangBradley D Olsen
Jan 10, 2021·Nature Communications·Rajkamal BaluNamita Roy Choudhury
Oct 13, 2012·Biomacromolecules·Julie N RennerJulie C Liu
Sep 3, 2013·ACS Macro Letters·Linqing Li, Kristi L Kiick
Dec 12, 2016·ACS Biomaterials Science & Engineering·Benjamin P PartlowDavid L Kaplan
Jun 29, 2011·Biomacromolecules·Angelo BracalelloAntonietta Pepe
May 8, 2017·ACS Biomaterials Science & Engineering·Lisa D Muiznieks, Fred W Keeley
Aug 14, 2017·ACS Biomaterials Science & Engineering·Sheng-Chen HuangXiao-Xia Xia
Oct 17, 2013·Biomacromolecules·Brigida BochicchioAntonietta Pepe
Oct 23, 2021·ACS Biomaterials Science & Engineering·Antonietta PepeBrigida Bochicchio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.