Cow´s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow´s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow´s milk allergens. Here, we provide an overview about the allergen molecules in cow´s milk and the advantages of the molecular diagnosis of IgE sensitization to cow´s milk by serology. In addition, we review current strategies for prevention and treatment of cow´s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.
Connection of atopic disease in Japanese patients with juvenile dermatomyositis based on serum IgE levels
Escherichia coli expression and purification of recombinant dog albumin, a cross-reactive animal allergen
Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children
Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy
Detection and identification of a soy protein component that cross-reacts with caseins from cow's milk
Interference in immunoassays by human IgM with specificity for the carbohydrate moiety of animal proteins
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment
Correlation between skin prick test using commercial extract of cow's milk protein and fresh milk and food challenges
Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI)
Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay
A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy
Cloning, expression, and mapping of allergenic determinants of alphaS1-casein, a major cow's milk allergen
Meta-analysis of the evidence for a partially hydrolyzed 100% whey formula for the prevention of allergic diseases
Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis: a meta-analysis
Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy
Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity
Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes.
Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy
Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study
Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy.
Patients suffering from non-IgE-mediated cow's milk protein intolerance cannot be diagnosed based on IgG subclass or IgA responses to milk allergens
Diagnosis and assessment of food allergy in children and young people in primary care and community settings: NICE clinical guideline.
Toward a standardized reading of the atopy patch test in children with suspected cow's milk allergy-related gastrointestinal symptoms
Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans
Biomarkers of the Severity of Honeybee Sting Reactions and the Severity and Threshold of Systemic Adverse Events During Immunotherapy.
Parallel Reaction Monitoring Mass Spectrometry Method for Detection of Both Casein and Whey Milk Allergens from a Baked Food Matrix.
Optimising the use of proteins from rich meat co-products and non-meat alternatives: Nutritional, technological and allergenicity challenges.
Clinical Trials Mentioned
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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
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