Molecular architecture of lineage allocation and tissue organization in early mouse embryo.

Nature
Guangdun PengNaihe Jing

Abstract

During post-implantation development of the mouse embryo, descendants of the inner cell mass in the early epiblast transit from the naive to primed pluripotent state1. Concurrently, germ layers are formed and cell lineages are specified, leading to the establishment of the blueprint for embryogenesis. Fate-mapping and lineage-analysis studies have revealed that cells in different regions of the germ layers acquire location-specific cell fates during gastrulation2-5. The regionalization of cell fates preceding the formation of the basic body plan-the mechanisms of which are instrumental for understanding embryonic programming and stem-cell-based translational study-is conserved in vertebrate embryos6-8. However, a genome-wide molecular annotation of lineage segregation and tissue architecture of the post-implantation embryo has yet to be undertaken. Here we report a spatially resolved transcriptome of cell populations at defined positions in the germ layers during development from pre- to late-gastrulation stages. This spatiotemporal transcriptome provides high-resolution digitized in situ gene-expression profiles, reveals the molecular genealogy of tissue lineages and defines the continuum of pluripotency states in time and spa...Continue Reading

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Citations

Nov 16, 2019·Science·Patrick P L Tam
Oct 11, 2019·Journal of Molecular Cell Biology·Guizhong CuiGuangdun Peng
Jan 10, 2020·Cell Proliferation·Zhen GuQi Gu
May 22, 2020·Current Protocols in Mouse Biology·Kristen S Barratt, Ruth M Arkell
Apr 28, 2020·Annual Review of Genomics and Human Genetics·Guangdun PengNaihe Jing
Sep 23, 2020·Life Science Alliance·Andreas Fønss Møller, Kedar Nath Natarajan
Dec 31, 2019·Molecular Systems Biology·Hanna L Sladitschek, Pierre A Neveu
Jul 17, 2020·Protein & Cell·Ruimin XuShaorong Gao
Jul 31, 2020·Nature·Stefanie GrosswendtAlexander Meissner
Dec 15, 2020·Developmental Cell·Carolina GuibentifJohn C Marioni
Dec 6, 2020·Cell Systems·Woo Jun ShimNathan J Palpant
Feb 15, 2021·Cellular and Molecular Life Sciences : CMLS·Lucy LeBlancJonghwan Kim
Dec 4, 2020·Cell Stem Cell·Masaki KinoshitaAustin Smith
May 31, 2020·Mechanisms of Development·Evan S Bardot, Anna-Katerina Hadjantonakis
May 23, 2020·Current Opinion in Biomedical Engineering·Anna-Katerina HadjantonakisMijo Simunovic
Dec 18, 2020·Developmental Biology·Berna SozenMagdalena Zernicka-Goetz
May 2, 2021·Cell·Markus MittnenzweigYonatan Stelzer
May 27, 2021·Briefings in Bioinformatics·Pengfei LiangYongchun Zuo
Jun 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yun YangLingfei Luo
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Daniela Ávila-GonzálezNéstor F Díaz
Aug 13, 2021·Nature·Anjali RaoItai Yanai
Sep 13, 2021·Development, Growth & Differentiation·Xun HuangAnming Meng
Jan 28, 2021·Cell Regeneration·Mengmeng JiangGuoji Guo

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Datasets Mentioned

BETA
E-MTAB-2958
E-MTAB-2959
15
GSE15268
GSE31544

Methods Mentioned

BETA
RNA-seq
Geo-seq
PCA
laser capture microdissection
dissection
Smart2-seq
PCR

Software Mentioned

Cytoscape
Vaa3D
pseudotime
MATLAB script
Geo
R
HTseq
WGCNA
FactoMineR
MEGA

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