Molecular architecture of poly[(R,S)-3-hydroxybutyrate-co-6-hydroxyhexanoate] and poly[(R,S)-3-hydroxybutyrate-co-(R,S)-2-hydroxyhexanoate] oligomers investigated by electrospray ionization ion-trap multistage mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Grazyna AdamusMarek Kowalczuk

Abstract

A series of aliphatic copolyesters was obtained from (R,S)-beta-butyrolactone and two isomeric hydroxy acids, 6-hydroxyhexanoic and (R,S)-2-hydroxyhexanoic acids. The reactions were conducted in bulk without catalyst. Electrospray ionization tandem mass spectrometry (ESI-MSn) was used for molecular characterization of these copolyester oligomers. The mass spectra of the copolyesters studied have enabled identification of their molecular structures including chemical nature of the end groups (hydroxyl and carboxylate). The compositions of the oligocopolyesters and their sequence distributions were determined based on measurement of the relative intensities of the individual oligocopolyester peaks in the ESI mass spectra. The mass spectra (MS1) provided information on composition and sequence distribution, and small deviations from Bernoulli statistics were detected. The arrangement of co-monomer structural units along the oligopolyester chains was verified by MS/MS experiments and investigation of the fragmentation pathways.

Citations

Nov 30, 2012·Journal of the American Society for Mass Spectrometry·Aleer M YolChrys Wesdemiotis
May 26, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Teruyuki SeinoHiroaki Tao
Jul 14, 2010·Mass Spectrometry Reviews·Chrys WesdemiotisBryan C Katzenmeyer
Jul 28, 2005·European Journal of Mass Spectrometry·Mark A ArnouldRafael Vargas
Jan 9, 2008·Biomacromolecules·Grazyna Adamus, Marek Kowalczuk
Jun 15, 2006·Analytical Chemistry·Patricia M Peacock, Charles N McEwen

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