Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors.

The Journal of Biological Chemistry
Lu DengR A Mariuzza

Abstract

Natural killer (NK) cells play a vital role in the detection and destruction of virally infected and tumor cells during innate immune responses. The highly polymorphic Ly49 family of NK receptors regulates NK cell function by sensing major histocompatibility complex class I (MHC-I) molecules on target cells. Despite the determination of two Ly49-MHC-I complex structures, the molecular features of Ly49 receptors that confer specificity for particular MHC-I alleles have not been identified. To understand the functional architecture of Ly49-binding sites, we determined the crystal structures of Ly49C and Ly49G and completed refinement of the Ly49C-H-2K(b) complex. This information, combined with mutational analysis of Ly49A, permitted a structure-based classification of Ly49s that we used to dissect the binding site into three distinct regions, each having different roles in MHC recognition. One region, located at the center of the binding site, has a similar structure across the Ly49 family and mediates conserved interactions with MHC-I that contribute most to binding. However, the preference of individual Ly49s for particular MHC-I molecules is governed by two regions that flank the central region and are structurally more varia...Continue Reading

References

Oct 3, 1998·Acta Crystallographica. Section D, Biological Crystallography·A T BrüngerG L Warren
Oct 6, 1999·Current Opinion in Structural Biology·K Drickamer
Aug 22, 2001·Immunological Reviews·S K AndersonD W McVicar
Apr 26, 2002·Current Opinion in Immunology·Eric VivierPascale Paul
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hamish R C SmithWayne M Yokoyama
Aug 17, 2002·Current Opinion in Immunology·Karina L McQueen, Peter Parham
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth T SilverKevin P Kane
Dec 17, 2002·Nature Structural Biology·Gürol M SüelRama Ranganathan
Apr 2, 2003·Nature Reviews. Immunology·Wayne M Yokoyama, Beatrice F M Plougastel
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian J MaKevin P Kane
Feb 20, 2004·Nature Immunology·Marie-Agnès DouceyWerner Held
Mar 3, 2004·Acta Crystallographica. Section D, Biological Crystallography·Laurent C StoroniRandy J Read
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Jun 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Beenu MozaEric J Sundberg
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jonathan BackWerner Held
Mar 1, 2008·Nature Reviews. Immunology·Werner Held, Roy A Mariuzza
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

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Citations

Feb 18, 2010·Virus Genes·Pamela L ShawRichard Longnecker
Jun 23, 2010·Immunology and Cell Biology·Hollie J PegramMichael H Kershaw
May 15, 2013·Nature Immunology·Richard BerryJamie Rossjohn
Jun 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yili LiRoy A Mariuzza
Dec 10, 2008·Blood·Colin G Brooks
Dec 5, 2012·PLoS Biology·William H McCoyDaved H Fremont
Jan 15, 2014·Immunology and Cell Biology·Richard BerryAndrew G Brooks
Nov 5, 2014·The Journal of Experimental Medicine·Tsukasa Nabekura, Lewis L Lanier
Nov 17, 2009·Immunogenetics·Melanie J DobromylskyjShirley A Ellis
Aug 25, 2011·Cellular and Molecular Life Sciences : CMLS·Werner Held, Roy A Mariuzza
Dec 18, 2009·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Aug 19, 2015·Immunological Reviews·Lisbeth A GuethleinPeter Parham
May 24, 2011·Journal of Structural Biology·Petr KolenkoJan Dohnálek
Apr 12, 2014·Frontiers in Immunology·Yili Li, Roy A Mariuzza
Aug 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian J Ma, Kevin P Kane
Oct 20, 2018·Nature Communications·Mizuho KajikawaKatsumi Maenaka
Dec 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Awndre GamacheMichael G Brown
Feb 25, 2009·Current Protocols in Immunology·Roberto Biassoni
Jan 10, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katarzyna M MickiewiczColin G Brooks
Jul 25, 2018·Current Protocols in Immunology·Roberto Biassoni, Mauro S Malnati
Apr 30, 2009·Journal of Leukocyte Biology·Derrick Gibbings, A Dean Befus
Apr 24, 2021·The Journal of Biological Chemistry·Jiaqi MaBrian M Baker
Jun 22, 2021·Current Opinion in Immunology·Hau V Truong, Nikolaos G Sgourakis
Aug 7, 2021·Pathogens·John M CronkMichael G Brown

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