Molecular architecture of tight junctions

Annual Review of Physiology
L L Mitic, J M Anderson

Abstract

The tight junction creates a regulated barrier in the paracellular pathway and, together with the actin-rich adherens junction, forms a functional unit called the apical junction complex. A growing number of tight junction-associated proteins have been identified, but functions are defined for only a few. The intercellular barrier is formed by rows of the transmembrane protein occludin, which is bound on the cytoplasmic surface to ZO-1 and ZO-2. These proteins are members of the membrane-associated guanylate kinase (MAGUK) protein family and are likely to have both structural and signaling roles. Junctional plaque proteins without known functions include cingulin, p130, and 7H6; single reports describe ZA-1TJ and symplekin. Many cellular signaling pathways affect assembly and sealing of junctions. Transducing proteins, which localize within the junction, include both heterotrimeric and rho-related GTP-binding proteins, PKC-zeta and nonreceptor tyrosine kinases. Control of perijunctional actin may be the unifying mechanism for regulating paracellular permeability.

References

Sep 1, 1976·The Journal of Cell Biology·R RodewaldM J Karnovsky
Jan 1, 1992·Annals of the New York Academy of Sciences·J L MadaraP Kaoutzani
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KitamuraI M Arias
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B GumbinerD Apatira
Jan 1, 1990·Annual Review of Biochemistry·M Takeichi
Oct 1, 1989·The American Journal of Physiology·B R StevensonM S Mooseker
Dec 1, 1988·The American Review of Respiratory Disease·M CereijidoR G Contreras
May 19, 1988·Nature·S CitiJ Kendrick-Jones
Jan 1, 1974·International Review of Cytology·L A Staehelin
Jul 31, 1981·Science·B Kachar, P Pinto da Silva
Apr 1, 1993·The American Journal of Physiology·M S Balda, J M Anderson
May 1, 1994·The Journal of Cell Biology·E WeberD R Abrahamson
Oct 1, 1993·Current Opinion in Cell Biology·J M AndersonA S Fanning
Dec 1, 1993·The Journal of Cell Biology·S TsukitaS Tsukita
Dec 1, 1993·The Journal of Cell Biology·M FuruseS Tsukita
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E WillottJ M Anderson
Oct 1, 1993·The Journal of Cell Biology·M S BaldaJ M Anderson
Feb 1, 1996·The Journal of Cell Biology·A K RajasekaranE Rodriguez-Boulan
Aug 1, 1996·The Journal of Cell Biology·B H KeonW W Franke
Feb 1, 1996·The Journal of Membrane Biology·V Dodane, B Kachar

❮ Previous
Next ❯

Citations

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KawaguchiK Tanikawa
Dec 3, 1999·Biochemical and Biophysical Research Communications·T KojimaD C Spray
Apr 25, 2000·Biochemical and Biophysical Research Communications·I Y Dobrosotskaya, G L James
Apr 17, 2008·Histochemistry and Cell Biology·Carola Förster
Aug 9, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michel Baum
Oct 22, 2011·Annals of Biomedical Engineering·Jarett E Michaelson, Hayden Huang
Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·Uros GregorcBoris Turk
Jun 27, 2013·Pharmaceutical Research·Céline Passeleu-Le BourdonnecSophie Martel
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yuri PersidskyGeorgette D Kanmogne
Sep 19, 2001·Current Gastroenterology Reports·A NusratA Neish
Nov 5, 2003·Advanced Drug Delivery Reviews·Silvia R da CostaSarah F Hamm-Alvarez
Jun 12, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D PizzutiD Martines
Apr 23, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Chong Huat Siar, Syed Amjad Abbas
Jan 19, 2008·Theory in Biosciences = Theorie in Den Biowissenschaften·Bernd Rosslenbroich
Oct 10, 2001·Fertility and Sterility·G I Gorodeski
Mar 14, 2003·Mechanisms of Ageing and Development·Arshag D MooradianJoe M Chehade
Nov 3, 2001·Brain Research. Brain Research Reviews·S M GloorK Frei
Jun 16, 2000·Advanced Drug Delivery Reviews·S V WalshA Nusrat
Jan 18, 2003·Progress in Neurobiology·Margaret A Petty, Eng H Lo
Jul 29, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L Illum
Dec 5, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P J Gaillard, A G de Boer
Oct 6, 1999·Current Opinion in Cell Biology·S TsukitaM Itoh
Sep 12, 2000·Current Opinion in Genetics & Development·E Knust
Jan 20, 2000·Trends in Cardiovascular Medicine·G BazzoniE Dejana
Jun 6, 2003·Microbes and Infection·Daniel F Balkovetz, Jannet Katz
Sep 2, 1999·Pharmaceutical Science & Technology Today·S D Krämer
Oct 12, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Murray B ResnickVictor E Pricolo
Sep 29, 2001·Development, Growth & Differentiation·D NanbaY Hieda
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KawaguchiM Sata
Jan 4, 2001·The Journal of Experimental Medicine·D DombrowiczM Capron
Sep 10, 2009·Antioxidants & Redox Signaling·Sarah K HartenPatrick H Maxwell

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
dissection

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.