Molecular aspects of bovine cystic ovarian disease pathogenesis

Reproduction : the Official Journal of the Society for the Study of Fertility
H H OrtegaN R Salvetti

Abstract

Cystic ovarian disease (COD) is one of the main causes of reproductive failure in cattle and causes severe economic loss to the dairy farm industry because it increases both days open in the post partum period and replacement rates due to infertility. This disease is the consequence of the failure of a mature follicle to ovulate at the time of ovulation in the estrous cycle. This review examines the evidence for the role of altered steroid and gonadotropin signaling systems and the proliferation/apoptosis balance in the ovary with cystic structures. This evidence suggests that changes in the expression of ovarian molecular components associated with these cellular mechanisms could play a fundamental role in the pathogenesis of COD. The evidence also shows that gonadotropin receptor expression in bovine cystic follicles is altered, which suggests that changes in the signaling system of gonadotropins could play a fundamental role in the pathogenesis of conditions characterized by altered ovulation, such as COD. Ovaries from animals with COD exhibit a disrupted steroid receptor pattern with modifications in the expression of coregulatory proteins. These changes in the pathways of endocrine action would trigger the changes in proli...Continue Reading

References

Sep 1, 1990·Journal of Reproduction and Fertility·D L CookH A Garverick
Jan 1, 1988·Journal of Animal Science·M Garcia-WinderE K Inskeep
Nov 1, 1987·Journal of Animal Science·G P Moberg
Nov 1, 1982·Journal of Animal Science·D J Kesler, H A Garverick
Oct 6, 1995·Science·C M KnudsonS J Korsmeyer
Dec 1, 1994·Endocrine Reviews·A J HsuehA Tsafriri
Oct 29, 1993·Annals of the New York Academy of Sciences·R M Liptrap
Jun 1, 1993·Endocrine Reviews·D L Segaloff, M Ascoli
Jan 1, 1996·American Journal of Obstetrics and Gynecology·A ShushanS Mor-Yosef
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Jun 7, 1996·Biochimica Et Biophysica Acta·S I Reed
May 1, 1996·Clinical Endocrinology·G AlmahbobiA O Trounson
Dec 1, 1996·Biology of Reproduction·O J GintherK Kot
Feb 7, 1997·Cell·R M ZwijsenR J Michalides
May 1, 1997·Journal of Dairy Science·H A Garverick
Sep 1, 1996·Reviews of Reproduction·J L Tilly
May 2, 1998·The EMBO Journal·C ScaffidiM E Peter
Jun 1, 1997·Baillière's Clinical Obstetrics and Gynaecology·S G Hillier, M Tetsuka
Aug 26, 1998·Biology of Reproduction·R L Robker, J S Richards
Jan 26, 1999·Advances in Immunology·P H Krammer
Feb 20, 1999·The Journal of Biological Chemistry·J Takeo, S Yamashita
Apr 20, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R OdoreC Girardi
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·M M MontanoB S Katzenellenbogen
Dec 28, 1999·Biology of Reproduction·S L VickersS M Quirk
Jul 25, 2000·Biology of Reproduction·K P NephewR M Bigsby

❮ Previous
Next ❯

Citations

Jun 1, 2018·The Journal of Veterinary Medical Science·Silviu Ionut BorșAlina Borș
Aug 19, 2018·Reproduction in Domestic Animals = Zuchthygiene·Valentina MatillerNatalia R Salvetti
May 29, 2016·The Biochemical Journal·Joëlle Dupont, Rex J Scaramuzzi
Aug 4, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Pablo U DíazNatalia R Salvetti
Aug 21, 2020·The Journal of Veterinary Medical Science·Silviu-Ionuț BorŞ, Alina BorŞ

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis