PMID: 11324697Apr 28, 2001Paper

Molecular aspects of HLA class II alphabeta heterodimers associated with IDDM susceptibility and protection

Reviews in Immunogenetics
R A Ettinger, G T Nepom

Abstract

HLA-DQ alleles are strongly associated with IDDM susceptibility and protection. Studies assessing the molecular properties of HLA-DR, a HLA class II locus in linkage disequilibrium with HLA-DQ, have made substantial contributions toward elucidating the structure and function of HLA class II molecules. Reports on the molecular properties of HLA-DQ are now following and have revealed interesting observations regarding the stability of HLA-DQ alphabeta heterodimers. Future work is expected to provide an understanding of the mechanism by which HLA-DQ is associated with IDDM susceptibility and protection.

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