PMID: 8974057Oct 1, 1996Paper

Molecular aspects of mechanical stress-induced cardiac hypertrophy

Molecular and Cellular Biochemistry
T YamazakiY Yazaki

Abstract

To elucidate the signal transduction pathway from external stimuli to nuclear gene expression in mechanical stress-induced cardiac hypertrophy, we examined the time course of activation of protein kinases such as Raf-1 kinase (Raf-1), mitogen-activated protein kinase kinase (MAPKK), MAP kinases (MAPKs) and 90-kDa ribosomal S6 kinase (p90rsk) in neonatal rat cardiomyocytes. Mechanical stretch rapidly activated Raf-1 and its maximal activation was observed at 1-2 min after stretch. The activity of MAPKK was also increased by stretch, with a peak at 5 min after stretch. In addition, MAPKs and p90rsk were maximally activated at 8 min and at 10-30 min after stretch, respectively. Next, the relationship between mechanical stress-induced hypertrophy and the cardiac renin-angiotensin system was investigated. When the stretch-conditioned culture medium was transferred to the culture dish of non-stretched cardiac myocytes, the medium activated MAPK activity slightly but significantly, and the activation was completely blocked by the type 1 angiotensin II receptor antagonist, CV-11974. However, activation of Raf-1 and MAPKs provoked by stretching cardiomyocytes was only partially suppressed by pretreatment with CV-11974. These results sug...Continue Reading

References

Jul 30, 1992·Nature·J M KyriakisJ Avruch
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Sep 15, 1987·Biochemical and Biophysical Research Communications·S L MulvaghM D Schneider
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Citations

Nov 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Quan HeMargot C LaPointe
Jan 27, 2019·Nature Reviews. Cardiology·Jeffrey J SaucermanJeffrey H Omens
Apr 18, 2007·Artificial Organs·Ligia H ArrudaIsmar N Cestari
Feb 10, 1999·The American Journal of Physiology·B K Dieckgraefe, D M Weems
Jul 18, 2001·Journal of Applied Physiology·L C Martineau, P F Gardiner
Oct 12, 1999·The American Journal of Physiology·M LiuM Post
Nov 19, 2008·The Journal of Membrane Biology·Xuxia LiuWeizhen Niu
Jun 20, 2013·BioMed Research International·Wayne Carver, Edie C Goldsmith
Apr 29, 2021·Journal of Biomedical Science·Lucia Sophie KilianAshraf Yusuf Rangrez

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