Molecular aspects of monoamine oxidase B

Progress in Neuro-psychopharmacology & Biological Psychiatry
R R Ramsay

Abstract

Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets. MAO B structure, function and kinetics are described as a background for the effect of alterations in its activity on behavior. The need to inhibit MAO B to combat decreased brain amines continues to drive the search for new drugs. Reversible and irreversible inhibitors are now designed using data-mining, computational screening, docking and molecular dynamics. Multi-target ligands designed to combat the elevated activity of MAO B in Alzheimer's and Parkinson's Diseases incorporate MAO inhibition (usually irreversible) as well as iron chelation, antioxidant or neuroprotective properties. The main focus of drug design is the catalytic activity of MAO, but the imidazoline I2 site in the entrance cavity of MAO B is also a pharmacological target. Endogenous regulation of MAO B expression is discussed briefly in light of new studies measuring mRNA, protein, or activity in healthy and degenerative samples, including the effect of DNA methylation on the expression. Overall, this review focuses on examples of recent research on the molecular aspects of the...Continue Reading

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Citations

Mar 22, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nela Pivac, Rona R Ramsay
Jan 5, 2017·Chemistry : a European Journal·Aleksandra Maršavelski, Robert Vianello
May 16, 2017·Future Medicinal Chemistry·Damijan KnezStanislav Gobec
May 26, 2017·Proteomics·Sausan AzzamKingman P Strohl
Aug 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nafiz Öncü CanZafer Asım Kaplancıklı
Aug 21, 2018·Current Drug Targets·Jahangir Alam, Lalit Sharma
Jan 4, 2019·Medicinal Research Reviews·Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan
Jul 22, 2019·Experimental Biology and Medicine·Adith S ArunKatherine L Wilson
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Qiuyue XuBin Yuan
Dec 31, 2020·Bioorganic Chemistry·Valeria A PanovaKyrill Yu Suponitsky
Mar 25, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mamangam Subaraja, Arambakkam Janardhanam Vanisree
Jul 22, 2021·Current Issues in Molecular Biology·Zoran MadzaracNela Pivac
Aug 10, 2021·Neurotoxicology·Daniela Silva-AdayaMaría E Gonsebatt

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