Molecular assays for antimalarial drug resistance surveillance: A target product profile.

PloS One
Christian NsanzabanaIveth J González

Abstract

Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. H...Continue Reading

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Citations

Dec 11, 2019·Tropical Medicine and Infectious Disease·Christian Nsanzabana
Feb 6, 2019·Tropical Medicine and Infectious Disease·Christian Nsanzabana
May 12, 2020·BMC Medicine·Paola CoccoBethany Shinkins
Jul 16, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hanna Y EhrlichSunil Parikh
Aug 2, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Yaye Die NdiayeSarah K Volkman
Aug 6, 2021·Expert Review of Anti-infective Therapy·Charlotte RasmussenPascal Ringwald

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping
nucleic acid amplification

Software Mentioned

FIND

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