Molecular-based mechanisms of Mendelian forms of salt-dependent hypertension: questioning the prevailing theory

Hypertension
Theodore W KurtzR Curtis Morris

Abstract

This critical review directly challenges the prevailing theory that a transient increase in cardiac output caused by genetically mediated increases in activity of the ENaC in the aldosterone sensitive distal nephron, or of the NCC in the distal convoluted tubule, accounts entirely for the hemodynamic initiation of all Mendelian forms of salt-dependent hypertension (Figure 1). The prevailing theory of how genetic mutations enable salt to hemodynamically initiate Mendelian forms of salt-dependent hypertension in humans (Figure 1) depends on the results of salt-loading studies of cardiac output and systemic vascular resistance in nongenetic models of hypertension that lack appropriate normal controls. The theory is inconsistent with the results of studies that include measurements of the initial hemodynamic changes induced by salt loading in normal, salt-resistant controls. The present analysis, which takes into account the results of salt-loading studies that include the requisite normal controls, indicates that mutation-induced increases in the renal tubular activity of ENaC or NCC that lead to transient increases in cardiac output will generally not be sufficient to enable increases in salt intake to initiate the increased BP t...Continue Reading

References

Nov 1, 1979·Hypertension·A W MillerJ M Terris
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J P MontaniA C Guyton
Apr 1, 1988·The American Journal of the Medical Sciences·C M FerrarioK B Brosnihan
Apr 1, 1987·Hypertension·J M SullivanM J Connor
Jun 1, 1980·The American Journal of Medicine·A W Cowley
Mar 10, 2001·Cell·R P LiftonD S Geller
Jul 16, 2003·Cold Spring Harbor Symposia on Quantitative Biology·R P LiftonD S Geller
Mar 30, 1963·Lancet·J G BORST, A BORST-DE GEUS
Sep 14, 2004·Journal of Hypertension·Michael ObstFriedrich C Luft
Jun 6, 2008·American Journal of Physiology. Renal Physiology·Peijun P ShiBaoli Yang
Apr 30, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hong-Wei WangFrans H H Leenen
Feb 2, 2011·Hypertension·Matthew A BaileyJohn J Mullins
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hyun Woo ParkMin Goo Lee
Jul 6, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hakan R TokaAli Hariri
Mar 6, 2013·Hypertension·Pia JeggleKristina Kusche-Vihrog
May 29, 2013·Clinical and Experimental Pharmacology & Physiology·Cara J Büsst
Sep 21, 2013·Pflügers Archiv : European journal of physiology·Kristina Kusche-VihrogHans Oberleithner
Oct 11, 2013·Kidney International·Jens TitzeFriedrich C Luft
Jan 1, 2014·Current Opinion in Nephrology and Hypertension·Kristina Kusche-VihrogFrédéric Jaisser

❮ Previous
Next ❯

Citations

Feb 26, 2016·Current Hypertension Reports·Paolo ManuntaGiuseppe Bianchi
Aug 16, 2016·Frontiers in Physiology·Holly Digne-MalcolmKeith L Dorrington
Feb 1, 2018·Journal of Hypertension·Cheryl L Laffer, Fernando Elijovich
Feb 1, 2018·Journal of Hypertension·Theodore W KurtzR Curtis Morris
Apr 4, 2017·Journal of the American Heart Association·Theodore W KurtzR Curtis Morris
Aug 10, 2016·Journal of the American Heart Association·Paolo CastiglioniPaolo Coruzzi
Dec 21, 2018·Hypertension·Theodore W KurtzR Curtis Morris
Mar 10, 2020·Circulation·Mateusz SiedlinskiTomasz J Guzik
Nov 20, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger G Evans, Peter Bie
Jun 24, 2017·American Journal of Hypertension·Theodore W KurtzR Curtis Morris
Dec 15, 2015·Journal of Cardiovascular Pharmacology·Kristina S LyngsøPernille B L Hansen
Jan 15, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Johannes Wild, Philip Wenzel
Oct 28, 2019·Endocrinology and Metabolism Clinics of North America·Filippo Ceccato, Franco Mantero
May 16, 2017·Kidney International·Jens Titze, Friedrich C Luft
Jul 23, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koichi Yamamoto, Hiromi Rakugi
Nov 18, 2021·The New England Journal of Medicine·David H Ellison, Paul Welling

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

Deutsche medizinische Wochenschrift
M Kögel
Periodontology 2000
Thomas C Hart, Jane C Atkinson
The British Journal of Ophthalmology
R K Blach, B Jay
Community Practitioner : the Journal of the Community Practitioners' & Health Visitors' Association
Louise Naughton
© 2022 Meta ULC. All rights reserved